PhD position "-Chip Separation of Proteins Single-Cell Proteome Profiling

Job description

• You will be developing a platform for the detection of protein production and secretion in single cells. An example of application is to study antibody secretion in immune cells upon their activation
• You will be optimizing recently established scanning nanopore microscope for specific detection of proteins in complex physiological solutions, addressing these open research challenges :
• Specificity of the sensor towards selected proteins :
  Enhancing the contrast for specific proteins
• Data analysis :
  Improving data analysis approaches for capturing more information from each individual protein
• Sampling from single cells :
  Developing methods for better sampling from individual cells, and handling of small volume samples
• You will be collaborating with colleagues from the machine learning domain to improve data analysis
• You will be responsible for project meetings, reporting, scientific publications, and conference / seminar presentations
• You will supervise master / bachelor students

• Solid working knowledge in either on-chip protein separation, microfluidics or nanofluidic.
• Hands-on experience with protein samples.
• Working experience in cell labs is valuable.
• Familiarity with data analysis using bioinformatic tools is highly valuable.
• Independent personality, self-driven, creative, solution-oriented, open-minded, team-player & collaborative.