PhD Position in Advanced 3D Organotypic Bone Models In Vitro Osteosynthesis Research

PhD Position in Advanced 3D Organotypic Bone Models for In Vitro Osteosynthesis Research

The Laboratory for Bone Biomechanics (LBB) at the Institute for Biomechanics at ETH Zurich is offering a PhD position in 3D bone tissue engineering. This position is embedded within the SNF Interdisciplinary Project ''Facilitating a paradigm shift in osteosynthesis:
Controlling biodegradation of magnesium alloys and their local effect on surrounding tissue'' (. ). The focus is on developing advanced organotypic in vitro bone models to study degradable osteosynthesis systems based on magnesium (Mg) alloys.

Mg-based biodegradable systems can resorb naturally after bone repair, reducing the need for implant removal. However, the degradation rate and biological effects remain insufficiently understood, and existing in vitro models fail to accurately reproduce the dynamic in vivo environment of bone healing. The overall goal of this project is to engineer an advanced organotypic 3D bone culture system that better replicates the biophysical and biochemical conditions of bone healing, enabling systematic evaluation of material‑cell interactions under physiologically relevant conditions.

The project involves a multidisciplinary collaborative approach across four laboratories at three leading Swiss institutions. The research will be conducted collaboratively across four laboratories at three leading Swiss institutions, combining material surface development, in vivo analysis, advanced in vitro modeling, and small‑animal testing.

• Development of 3D organotypic bone models to reduce in‑vitro‑in‑vivo discrepancies in studying magnesium alloy biodegradation
• Establishment of bioreactor‑based culture systems replicating in‑vivo conditions such as pH, Mg ion concentration, and pressure
• Analysis of material‑cell interactions under dynamic loading using analytical and molecular techniques

• MSc degree in biomedical engineering or related discipline
• Previous experience in tissue engineering and cell culture is required
• Experience in data analysis in Python is advantageous
• Experience with imaging (especially computed tomography) and/or image analysis is advantageous
• Excellent communication skills in English (oral and written) are mandatory
• High motivation, strong interest in skeletal research, and resilience to tackle challenges
• Ability to solve complex tasks independently
• Familiarity with a cross‑cultural, interdisciplinary environment is an advantage

• Access to state‑of‑the‑art research infrastructure, including bioprinters, imaging platforms, and advanced cell culture facilities
• Working in a highly committed multidisciplinary team
• Regular meetings and close collaboration with project partners
• Enrollment in the PhD program of ETH Zurich
• Family‑friendly environment with excellent working conditions, cultural diversity, and attractive benefits

ETH Zurich promotes an inclusive culture, equality of opportunity, and a working environment that respects the rights and dignity of all staff and students. The university is committed to climate‑neutral goals and fostering a sustainable future.

We look forward to receiving your online application with the following documents:

• University transcripts
• Names and contact details of two references

Applications must be submitted exclusively through the online portal; emails and postal services will not be considered.

Further information regarding the Laboratory for Bone Biomechanics can be found on our website. Questions regarding the position should be directed to Prof. Dr. Ralph Müller at ram.

In your application, please refer to