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Post Doc - Wolfe Lab

Job in Worcester, Worcester County, Massachusetts, 01609, USA
Listing for: University of Massachusetts
Full Time position
Listed on 2026-03-12
Job specializations:
  • Research/Development
    Research Scientist, Medical Science
  • Healthcare
    Medical Science
Salary/Wage Range or Industry Benchmark: 80000 - 100000 USD Yearly USD 80000.00 100000.00 YEAR
Job Description & How to Apply Below

Overview

The Wolfe laboratory will be filling a postdoctoral position to develop therapeutic genome editing reagents for muscular dystrophies and cancer. These projects will focus on:

  • the development of prime editing reagents with high activity and specificity for the precise correction of common pathogenic mutations associated with Limb Girdle Muscular Dystrophy;
  • the development of genome editing reagents for selective killing of cancer cells harboring gene amplifications;
  • the utilization of unbiased genome‑wide techniques for assessing off‑target events and other genomic alterations potentially associated with genome editing;
  • the translation of the developed genome editing reagents to clinical application through in‑vivo safety and efficacy studies in relevant mouse models.
  • Responsibilities

    These studies will expose the successful candidate to cutting‑edge genome editor engineering approaches and the delivery of these reagents in vivo via AAV or lipid nanoparticles. The successful candidate will also learn cutting‑edge deep‑sequencing approaches to evaluate off‑target editing within the genome, and will have the opportunity to participate in meetings and conferences associated with genome editing and gene therapy, broadening their exposure to pioneering research within the field.

    Qualifications
    • Candidates should have a degree in biology, biochemistry, chemistry or a related biomedical science.
    • Strong oral and written communication skills and eagerness to present research results at national meetings.
    • Prior experience with genome editing systems, cell culture, deep‑sequencing technologies and mouse disease models is advantageous but not required.

    Applicants should send a letter (via email) describing their current research activities and their interest in this position, a CV (including publications) and contact information for three references, including your advisor. Address letters to Scot Wolfe.

    University of Massachusetts Chan Medical School
    Department of Molecular, Cell and Cancer Biology
    364 Plantation Street, LRB Room 619
    Worcester, MA 01605

    Posting Disclaimer

    This job posting outlines the primary responsibilities and qualifications for the role but is not intended to be an exhaustive list. Duties and expectations may evolve in response to the needs of the department and the broader institution.

    In alignment with our commitment to pay transparency, the base salary range for this position is listed above (exclusive of benefits and retirement). At UMass Chan Medical School, final base salary offers are determined based on a combination of factors, including your skills, education, and relevant experience. We also consider internal equity to ensure fair and consistent compensation across our teams.

    In addition to base pay, UMass Chan offers a comprehensive Total Rewards package, which includes paid time off, medical, dental, and vision coverage, and participation in a 401(a) retirement plan, with the option to contribute to a voluntary 403(b) plan.

    UMass Chan welcomes all qualified applicants and complies with all state and federal anti‑discrimination laws.

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