Senior Associate Engineer II, Supply Chain & External Manufacturing

Senior Associate Engineer II, Supply Chain & External Manufacturing

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Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one‑time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high‑value programs, each targeting a disease with well‑understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities.

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We are seeking a talented Senior Associate Engineer II for the Supply Chain and External Manufacturing organization to serve as a primary point of contact representing Prime Medicine for key external partners and support non‑clinical development and CMC/manufacturing across Technology, Development & Operations (TDO). This includes relationship and project management for CDMOs, CTLs, CROs and other critical suppliers. The role is focused on defining clear scopes of work, negotiating and managing SOWs/SOCs and change orders, proactively planning and managing risk, and ensuring tight alignment between internal teams and external partners.

The ideal candidate is a highly creative and collaborative engineer with excellent project management skills, a roll‑up‑your‑sleeve and solution‑oriented attitude who is comfortable learning new things, wearing multiple hats, and operating in a fast‑paced, evolving environment.

This role reports to the Director of Supply Chain and External Manufacturing.

• Serve as the primary point of contact and project manager for assigned CDMO, CTL, CRO and other external partners across both non‑clinical and CMC projects and activities.
• Coordinate communications between Prime technical experts and external partners, prioritizing and facilitating external project team meetings.
• Coordinate with logistics providers and partners on shipment of materials, intermediates, and finished products between Prime and external sites ensuring compliance with relevant shipping and regulatory requirements (permits, customs, chain of custody, temperature control).
• Build strong, trust‑based relationships and drive continuous improvement in performance and ways of working.
• Collaborate with stakeholders in Non‑Clinical Development, CMC/Manufacturing and Quality, Program Management, Finance, Legal and others to align on objectives, expectations and priorities for external work.
• Translate program strategies into clear, actionable SOWs/SOCs with defined deliverables, timelines, and roles/responsibilities.
• Collaborate with Legal, Finance, Procurement and technical SMEs on MSAs, Quality/Technical Agreements, SOWs/SOCs and amendments.
• Own the operational aspects of SOW/SOC and change‑order management.
• Support budget tracking and financial planning for assigned vendors (forecasts, accrual inputs, and cost/risk trade‑offs).
• Keep internal and external teams aligned as plans evolve with clear and concise documentation, as well as facilitating cross‑functional meetings focused on execution and decision‑making.
• Develop and maintain integrated project plans for external work streams aligned with overall program timelines and decision points.
• Monitor progress against milestones and KPIs and drive accountability to keep work on track.
• Develop and use…