Senior Laboratory Operations Associate

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well‑understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities.

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We are seeking a highly motivated Senior Laboratory Operations Associate with 3–5 years of hands‑on experience supporting high‑throughput, high‑hazard chemistry, vivarium, and GMP operations. This individual will play a critical role in ensuring the smooth operation of a dynamic laboratory environment. The ideal candidate has a deep understanding of management of high‑volume high hazard chemicals, asset management, is adaptable, detail‑oriented, and a strong cross‑functional communicator with a passion for operational excellence.

• Under the guidance of the Senior Laboratory Manager, manage day‑to‑day operations in high‑volume chemistry, biology, animal, and GMP laboratories, including supply management, asset management, chemical inventory, and waste handling.
• Oversee management and administration of laboratory instrument service agreements, remedial repair, scheduling preventative maintenance, and digital asset management system.
• Manage relationship with select vendors and suppliers.
• Oversee the receipt, organization, and distribution of reagents and consumables to support chemistry workflows including 55‑gallon drums of virgin chemicals and waste.
• Ensure appropriate segregation, labeling, storage, and disposal of high‑hazard chemicals, including Class A, Class B, water reactive materials, organic acids, inorganic acids, bases, and acutely toxic chemicals.
• Coordinate with chemists to prepare and dispose of solid‑phase resins, solvents, and purification materials in compliance with EHS protocols.
• Monitor and maintain process systems and chemicals in 780 CMR/International Building Code (IBC) §307 designated High‑Hazard Group Occupancy (H3 room).
• Collaborate with vivarium staff to support animal research workflows, including supply delivery, sanitization cycles, live animal deliveries, and carcass disposal in accordance with 105 CMR 480.000.
• Support cross‑functional workflows between R&D and GMP labs.
• Ensure documentation, materials movement, and environmental monitoring align with GMP compliance expectations.
• Other responsibilities as required.

• 3–5 years of direct hands‑on experience in laboratory operations within a biotechnology environment.
• Experience supporting high‑hazard chemistry, vivarium operations, GMP manufacturing, and BSL‑2 biology labs.
• Experience working in ISO 5, 7, and 8 cleanroom environments.
• Experience with ‘just‑in‑time’ supply chain management, KANBAN, 5S/Lean.
• Familiarity with lab and facility management systems (e.g., LIMS, CMMS, asset management).
• Comfortable working in environments requiring strict compliance: H3 occupancy, BSL‑2, vivarium, and GMP.
• Strong organizational and multitasking skills with an ability to work independently.
• Excellent communication skills, both verbal and written.
• Familiarity with 527 CMR 1.00, RCRA, EPA, DOT, HAZWOPPER, and IATA regulations.

• Ability to be on‑call to receive and respond to alarms within 1 hour.
• Ability to lift 50 lbs, stand for…