Scientist, Chemistry

Scientist, Chemistry at Treeline Biosciences

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Treeline Biosciences is a new biotechnology company, founded by an experienced team of biopharmaceutical scientists and executives, committed to developing new medicines against difficult‑to‑drug targets in cancer and other life‑threatening diseases. We are pursuing a uniquely integrated approach that applies modern and emerging tools in genomics, structural biology, medicinal chemistry, and computation to reduce the time and risks of drug discovery.

A Scientist of Chemistry is primarily responsible for proposing, synthesizing, and characterizing molecules as potential oncology therapeutics. The scientist will be responsible for driving the advancement of oncology programs and platforms by optimizing the potency, pharmacokinetics, safety and in vivo efficacy of potential oncology drugs.

• Design and improve synthetic routes to support SAR studies in a timely manner.
• Solve synthetic, characterization and purification challenges of complex molecules.
• Generate hypotheses, independently execute experiments, and use results to assist in the design of the next experiment.
• Recognize problems and provide input on solutions, suggest new approaches to established procedures to progress key drug discovery.
• Critically evaluate project data while rigorously driving data‑driven Go/No‑go decisions, including the identification of resource constraints and bottlenecks.
• Promote an overall group culture of agility, pro‑action, collaboration, and innovation.
• Mentor and develop internal talent.

• PhD in organic chemistry or related field (0–5 years industry experience and/or postdoctoral training) with compelling medicinal chemistry experience.
• Demonstrated expertise in synthetic organic chemistry with a record of productivity in the design, synthesis, purification, and characterization of challenging organic molecules using state‑of‑the‑art techniques.
• Excellent literature search skills, the ability to design and improve synthetic routes to support SAR studies and deliver compounds on suitable scale required to support research programs.
• Highly motivated, creative, and able to maintain excellent documentation of work with knowledge of cutting‑edge medicinal chemistry and synthetic chemistry techniques.
• Candidates must possess excellent collaboration skills, demonstrate strong analytical and organizational skills, and work effectively under aggressive timelines.
• Strong computer skills, including Sci Finder, Chemdraw, and related software.
• Excellent communication skills and the ability to report and present data to colleagues and senior management is required.

Salary: $110,508 to $141,560 annually (Watertown, MA). The final base salary will depend on experience, education, and other factors. Treeline is a multi‑state employer; this range may vary for positions in other cities or states.