Senior Scientist​/Principal Scientist, Cheminformatics and Computational Screening

Senior Scientist/Principal Scientist, Cheminformatics and Computational Screening

We are seeking an experienced cheminformatics scientist to join our innovative drug discovery team focused on developing next-generation therapeutics. This is a unique opportunity to be a key contributor to our small but growing company. Your primary responsibility is to lead the computational aspects of our experimental screening. As a small, nimble company, your cheminformatics skills will also be applied more broadly across other parts of the computational drug discovery process.

This is a hybrid position located in Watertown, MA.

Key Responsibilities

• Build, maintain, and improve data processing pipelines for phage display and APMS screening and other screening technologies as we add them.
• Design and apply analysis methods on screening results to collaborate with medicinal chemistry colleagues for follow-up compound selection.
• Design new combinatorial libraries, in collaboration with medicinal and analytical chemists, to further enhance our hit-finding capabilities.
• Build and apply cheminformatic tools and analyses to support the full drug discovery process.

Job Requirements

• B.S. in Computational Chemistry, Physical Chemistry, Materials Science, or Computer Science (with a cheminformatic focus) or a related field with 6+ years of Industrial experience, or Ph.D. (in the same fields) with 4+ years of Industrial experience.
• Experience with developing and applying analysis of experimental library screening with either next‑gen sequencing or mass spectrometry readouts.
• Expertise in at least one cheminformatics platform (e.g., RDKit, Open Eye) to run analyses such as clustering, chemical space diversity, featurization, and simple model building.
• Experience with cloud‑based computational infrastructure, particularly Google Cloud, is a plus.
• Proven ability to work collaboratively in a multidisciplinary environment, communicate effectively, and translate computational insights into actionable hypotheses.
• Passion for solving complex problems and contributing to cutting‑edge drug discovery.

Seniority level
:
Mid‑Senior level

Employment type
:
Full‑time

Job function
:
Research