Associate Director, Pathology

Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugate therapies. Our pipeline includes varegacestat, a late-clinical stage GSI; IM-1021, a clinical-stage ROR1 ADC; and IM-3050, a FAP-targeted radiotherapy that recently received IND clearance.

We are also advancing a broad portfolio of early stage ADCs pursuing undisclosed solid tumor targets.

This individual will be a core scientific leader within the Translational Sciences organization, driving the integration of anatomic pathology into early discovery, target validation, mechanistic research, and translational strategy for the company’s targeted oncology portfolio. In this highly cross-functional role, the individual will partner closely with discovery biology, translational medicine, bioinformatics, and clinical development to ensure that tissue-based science directly informs target liability assessments, translational relevance, and decision-making from concept through early clinical development.

This position requires expertise in veterinary anatomic pathology, a strong understanding of tumor biology and immuno-oncology, and a proven ability to collaborate across diverse scientific disciplines. This position will also partner directly with the internal histology laboratory to ensure high-quality tissue processing, staining, and analysis in support of discovery and translational studies.

Pathology Leadership & Scientific Strategy

• Serve as the subject matter expert in toxicologic pathology, disease pathogenesis, and tissue-based biomarker science.
• Provide strategic input on target biology, model selection, target liability, in vitro/in vivo alignment, and translational relevance across multiple therapeutic programs.

Histopathologic Evaluation & Advanced Tissue Analytics

• Perform expert histopathologic evaluation of tissues from discovery, preclinical, and clinical studies to characterize target expression, pathology phenotypes, mechanism of action, and biomarker distribution.
• Apply and guide the use of advanced tissue-based platforms, including IHC, ISH, multiplex imaging, and digital image analysis, to enable quantitative and comparative biology assessments.
• Integrate pathology findings with multi-omics and in vitro model data (including co-culture systems, organoids, and other cellular models) to strengthen biological insight and translatability.
• Ensure timely, high-quality pathology deliverables, including regulatory-ready written reports, to support internal decision-making and regulatory requirements.

Representation & Scientific Communication

• Represent Pathology and Translational Sciences in cross-functional team meetings, external collaborations, and scientific forums.
• Communicate complex pathology findings succinctly to diverse audiences, including research scientists, clinicians, senior leadership, and the public.
• Contribute to publications, presentations, and scientific strategies that showcase innovative approaches in tissue-based translational research.

• DVM/VMD, or equivalent.
• Board certification in veterinary pathology (ACVP/ECVP) required.
• Ph.D., Pharm
  
  D, MD, or equivalent in a relevant scientific discipline (e.g. cancer biology, toxicology, molecular pathology).
• Demonstrated expertise in IHC/ISH, multiplex imaging, digital pathology tools, and interpretation of tissue-based biomarkers.
• 4-10 years’ experience in discovery, translational research, or nonclinical development within biotech, pharma, or academic research; oncology and/or large-molecule experience strongly preferred.

• Strong grounding in tumor biology, cancer immunology, and molecular oncology relevant to targeted therapy development.
• Experience with designing, interpreting, and reporting exploratory pathology studies.
• Experience developing and qualifying/validating comparative biomarker assays.
• Ability to…