Director, Program Management

About Us

Crescent Biopharma’s vision is to build a world‑leading oncology company bringing the next wave of therapies for cancer patients. The Company’s pipeline includes its lead program, a PD‑1 x VEGF bispecific antibody, as well as novel antibody‑drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies either as single agents or as part of combination regimens to treat a range of solid tumors.

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The Director, Program Management (PM) will play a vital role in a high‑performing cross‑functional Program Team. The PM is responsible for a wide range of activities, including facilitating and driving execution across the drug development lifecycle. Working in partnership with the Program Team Leader (PTL) and functional experts, the PM is responsible for developing a fully‑integrated program plan supported by functional plans to deliver the strategic objectives of the program.

The PM drives team execution to deliver program goals. Proposing and evaluating options to balance the key priorities of quality, speed, and cost, the PM encourages robust dialogue within the team and facilitates arriving at team decisions. Clear and effective communication within the team and with company leadership is a key responsibility of the PM, working in concert with the PTL.

The PM is solutions‑oriented and comfortable operating amid ambiguity in a fast‑paced environment. With the PTL, the PM frames and facilitates effective discussions to achieve alignment and data‑driven decision‑making. The PM builds durable, trust‑based relationships with team members and stakeholders across the organization and effectively manages with influence.

• Lead the operations of one or more highly motivated cross‑functional Program Team, with focus on both the tangible aspects such as priorities, goal achievement, and resources, and the critical soft skills of maintaining a challenging, collaborative, and sustainable team environment
• Partner with the PTL to identify near, mid, and long‑term team priorities and propose path to address, including facilitation of appropriate strategic decision‑making
• Adhere to best practices for clear and open communication with Program Team, Crescent Senior Leadership, and other stakeholders regarding program status, priorities, risks/mitigations, and needs
• Drive execution of the established program vision and strategy, maintaining an emphasis on quality, speed, and cost
• Facilitate creation & maintenance of core program strategy documents such as the Target Product Profile (TPP), Clinical Development Plan (CDP), and Regulatory Strategy in collaboration with cross‑functional representatives and in alignment with the overall program strategy
• Support functional strategic and annual planning with up‑to‑date and fit‑for‑purpose materials to inform functional leaders and team representatives
• Responsible for creation and maintenance of detailed cross‑functional plans and integrated program plans and visualizations
• Maintains up‑to‑date knowledge of the rapidly evolving PD(L)-1/VEGF bispecific and ADC competitive landscape
• Drives the development and maintenance of the program‑level budget and long‑range plan, working in close collaboration with Finance and the cross‑functional team
• Provides alliance management support for the program, if applicable

• Bachelor’s degree in science or related field; advanced degree in a scientific discipline or MBA preferred
• 10+ years of relevant experience in biotech/pharmaceutical industry in positions of increasing responsibility in drug development
• Proficient with Microsoft Office Suite of programs (PowerPoint, Word, Excel, SharePoint, Teams), Smartsheet, and other communication and PM tools
• Understanding of current and evolving capabilities of artificial intelligence tools including limitations
• Strong analytical, strategic thinking, and problem‑solving skills
• Outstanding communication skills (verbal, written, oral); able to communicate clearly, openly, and consistently in a timely…