Manager, Payroll

Manager, Payroll

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

The Payroll Manager is responsible for supporting data management related to aspects of employee payroll processing within an organization. This position reports directly to Payroll Director.

• Process U.S. multi-state on-cycle payroll (semi‑monthly) for 850+ employees, including Puerto Rico, using ADP WFN.
• Prepare out-of‑cycle payroll (RSU, NQ, ISO, Termination).
• Ensure all payroll data is accurate, including employee hours, deductions, and benefits.
• Investigate and resolve payroll discrepancies in a timely manner.
• Implement system improvements to streamline payroll processes and enhance efficiency.
• Assist in 401K audit and workers’ compensation audit.
• Prepare journal entries and accruals related to payroll and equity.
• Conduct month‑end account reconciliations.
• Assist Payroll Director with quarter‑end, year‑end activities including W‑2 reconciliation.
• Provide excellent customer service by addressing payroll‑related inquiries and resolving issues in a timely manner.
• Partner with HR for equity reporting or discrepancies.
• Stay up‑to‑date with federal, state, and local regulations governing payroll, benefits, equity and ensuring compliance with all relevant laws.
• Generate regular reports on payroll and benefits metrics for management review, as well as preparing reports for external stakeholders such as auditors or regulatory agencies.
• Provide support to employees regarding payroll and benefits‑related inquiries, troubleshooting issues, and facilitating communication between employees and relevant vendors or departments.
• Collaborate with HR, finance, and other departments to ensure seamless coordination of payroll and benefits processes with other HR and financial activities.
• Stay current on ADP payroll system updates and training to ensure the highest return on investment for payroll system.
• Other activities and tasks assigned by Payroll Director.

• Bachelor’s degree preferred.
• 5+ years of payroll experience.
• ADP WFN experience is highly preferred.
• Proficient with Microsoft Office Excel (PIVOT Table, V‑Lookup, SUM IF).
• Excellent organizational and communication skills.
• Ability to prioritize workload.
• Attention to detail.
• Ability to work in a fast‑paced, ever‑changing environment.
• Versatile and flexible, with the ability to work independently on assigned tasks and take directives on given assignments.
• Knowledgeable in equity payroll processing and reporting requirements (including RSU, ESPP, ISO and NQ).
• Familiarity with year‑end payroll activities, including reconciliations and reporting.

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All full‑time employees receive equity, which reinforces our ownership culture. Base salary…