Director, US Commercial Business Operations

Director, US Commercial Business Operations

Waltham, MA

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease.

At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more , and follow us on X, Linked In and Facebook.

The Director, US Commercial Business Operations is a critical role within the commercial organization, driving strategic initiatives and operational excellence to fuel business growth. Reporting to the Head of US Commercial Operations, this individual is a highly visible commercial leader responsible for building foundational capabilities from the ground up, including operational infrastructure, data strategy, management, and governance; commercial effectiveness program development and execution;

and sales enablement.

This role requires strong cross‑functional collaboration across commercial stakeholders in marketing, market access, patient services, finance, IT, and US Commercial leadership to ensure launch readiness and sustained execution. The Director, US Commercial Business Operations serves as a champion of innovation and operational efficiency, streamlining processes and enhancing collaboration with a patient‑first mindset.

This is an individual contributor role requiring strong communication, self‑initiative, and consultative engagement skills. This role is based in Waltham, MA

• Establish scalable processes for forecasting, demand and sales planning, and performance tracking to ensure operational efficiency.
• Manage Veeva, BI tools, and other commercial technology systems to identify market trends, optimize resource allocation, and make data driven-informed decisions.
• In collaboration with Trade and Distribution lead and finance, create channel analytics to inform forecast demand.
• Collaborate with marketing operations for Medical/Legal Review Process logistics
• Partner with marketing operations on National, regional, and local meeting management.
• Lead automation of BI reporting for HQ, executive leadership and field in collaboration with IT commercial business partner.
• Embed AI tools and capabilities into key processes and workflows to improve efficiency, decision‑making, and business outcomes.
• Scalable process for alignments, targeting, and Veeva call cycle planning.
• Lead for market access analytics and developing reports through requirement gathering with HUB, SP, SIP and data aggregator.

• Implement and refine data strategy as needed.
• Oversee all data channels for US market, ensure quality, and set up processes to identify data issues
• Lead SP and data aggregator data integrity meeting process, setting weekly cross‑functional team engagements.
• Ensure data quality and compliance with security and regulatory standards.
• Lead data processes and foster collaboration to align organizational goals while driving continuous improvement.

• Lead field force programs and services, circle of excellence program development, award trip, and administration.
• Fleet program development and management.
• Optimize field enablement tools and materials for maximum field productivity.

• Bachelor’s degree and 10+ years of experience in biotech/pharma/life sciences in field sales, sales leadership, commercial business operations or strategy.
• Proven track record of success in launching rare disease neuromuscular, neurodegenerative or neurodevelopmental therapies.
• Strong leadership experience, managing vendors, and scaling commercial infrastructure.
• Strategic thinker with strong business acumen and results‑oriented mindset
• Proficiency with…