Associate Engineer , Process Engineering

Overview

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein.

Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics.

Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

As an Associate Engineer I, Process Engineering, you will play a critical role in our process engineering operations and contribute to continuous improvements to enhance efficiency, safety, and productivity. You will be responsible for promoting the smooth and efficient operation of our manufacturing processes. Core duties will include overseeing implementation of process/safety improvements, providing support to the processing team, and equipment management.

• Process Improvements
  • Collaborate with cross-functional teams to translate experimental findings into actionable process improvements.
  • Perform experiments in collaboration with your team to optimize existing processes or develop new ones.
  • Participate in process risk assessments and recommend mitigation strategies.
• New Process Integration
  • Support process transfer from Process Development.
  • Support process scale-up and commercialization.
• Process Safety
  • Participate in process safety evaluations, such as PSSR and PHA, for new processes, new equipment, modifications to processes, modifications to equipment and as seen fit.
  • Collaborate with manufacturing and safety teams to identify safety improvements.
  • Maintain safety systems to ensure the process remains in a ready state and future safety issues can be prevented.
  • Demonstrate and support a culture of safety awareness and compliance within the production team.
• Process Support
  • Provide technical support for production operations, identify and assist resolution of manufacturing issues.
• Process Equipment Management
  • Support manufacturing staff in the safe and effective use of new equipment.
  • Support equipment and process qualification activities and ensure compliance with regulatory requirements.
  • Assist with troubleshooting and repair of equipment internally when feasible.
• Process Monitoring and Troubleshooting
  • Troubleshoot process and equipment issues on the floor with manufacturing staff. Escalate to Maintenance as necessary.
  • Participate in routine process monitoring.
  • Support WI, SOP, and document updates for manufacturing equipment and systems.
• Documentation Management
  • Review and update P&IDs for production processes, including equipment, instrumentation, and piping systems.
  • Follow P&e management processes, including version control and documentation updates.
  • Reference the design and validation documentation for equipment to ensure compliance and design intent are maintained.
• Additional Duties as required:
  • Help develop batch records in a GMP environment.
  • Occasionally assist with production work as needed

• Bachelor’s degree in Chemical…