Postdoctoral Researcher
Listed on 2026-03-03
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Research/Development
Research Scientist, Clinical Research, Medical Science
Company Description
UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care.
UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.
UHN’s vision is to build A Healthier World and it’s only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.
Job Description
Union: Non-Union
Number of Vacancies: 2
New or Replacement Position: New
Site: Princess Margaret Cancer Research Tower
Department: Research
Reports To: Principal Investigator
Salary Range: $54,902 - $93,333 Annually
Hours: Per Week
Shifts: Monday-Friday
Status: Temporary Full-time (1 Year Contract)
Closing Date:
March 23, 2026
Position Summary:
We are seeking two exceptional Postdoctoral Researchers to join our team investigating GLP1-1 receptor agonists as a preventive strategy for clonal hematopoiesis-driven hematological cancers.
The Xie and Chan Laboratories are located at the Princess Margaret Cancer Centre in Toronto, Canada with full access to state-of-the-art facilities in Toronto's Discovery District. The labs employ advanced humanized and syngeneic animal models, CRISPR/Cas9 genome editing tools, functional assays, and single cell technologies to identify and investigate specific gene dependencies that drive clonal hematopoiesis.
Duties:
Develop and execute experimental protocols to investigate the biology of hematopoietic stem cells and mechanisms of clonal hematopoiesis with GLP-1 receptor agonism, using advanced molecular and cellular techniques
Perform comprehensive data analysis, including bioinformatics and statistical analysis, to interpret experimental results and draw meaningful conclusions.
Isolate and characterize hematopoietic stem cells from human donor samples or animal models, utilizing techniques such as flow cytometry, cell sorting, and other stem cell assays.
Work closely with other researchers, including graduate students and other post-doctoral fellows, to support ongoing projects and foster a collaborative research environment.
Stay updated on recent literature and advancements in clonal hematopoiesis research, identify new research opportunities, and propose novel hypotheses to explore within the lab’s focus area.
Prepare research findings for publication in peer-reviewed journals and contribute to writing grant applications to secure additional funding for research projects.
Mentor junior researchers, including graduate and undergraduate students, by providing guidance on experimental design, lab techniques, and data analysis.
Present research findings at lab meetings, seminars, and national or international conferences to share progress and gain feedback from the scientific community
Qualifications
Additional Information
Why join UHN?
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