Senior Scientist - Immunology​/Immunogenicity

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Scientist – Immunology/Immunogenicity

Let’s do this. Let’s change the world. The Department of Clinical Immunology within the Clinical Development at Amgen is seeking a highly motivated scientist to perform various in vitro assays to inform on the immunogenic risk of our protein therapeutic pipeline at the Amgen Thousand Oaks site. In this vital role, you will work closely with Clinical Immunology team members across sites, as well as other functional teams including Therapeutic Discovery, Research and Process Development.

Key responsibilities will include.

• Perform various cell-based assays using primary human cells, such as dendritic cell or B cell co-culture with T cells using T cell proliferation, cell surface expression, and cytokine production as a readout.
• Development novel in vitro assays to assess immunogenic risk.
• Collaborate with colleagues to execute MHC-associated peptide proteomics (MAPPs) experiments to identify potential T cell epitopes within protein therapeutic candidates.
• Design and/or modify assays based on the mechanism of action of the drug candidate.
• Implement the cell-based assays using an automated, high throughput platform.
• Generate data, interpret, and summarize results for presentation at internal meetings as needed.
• Summarize results into study reports for incorporation into regulatory documents.
• Mentor a lab-based scientific team, driving project execution while supporting individual growth and long-term career development

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications.

Basic Qualifications:

Doctorate Degree

Or

Master’s degree and 2 years in Immunology or related experience

Or

Bachelor’s degree and 4 years in Immunology or related experience

Preferred Qualifications:

• PhD with experience in the field of immunology with specific training in T cell and/or dendritic cell (DC) biology; T cell memory recall assays

• Technical expertise in cell culture, multi-color flow cytometry, complex cell-based functional assays using primary cells and cell-lines, internalization assays, and MAPPS.

• Knowledge of liquid handing and robotic platform.

• Strong verbal and written communication skills.

• Ability to work independently in a diverse, cross-functional team environment.

• High degree of flexibility to adapt to different projects and shifting priorities

As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.

In addition to the base salary, Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus