Scientist, Antibody Engineering

Job Title:

Scientist, Antibody Engineering
Job Type: Full-time, permanent

Are you passionate about making life science life changing and delivering impact for patients? We want to hear from you.

The Scientist, Antibody Engineering role at Life Arc offers the prospect of being fully involved in multiple antibody humanisation or discovery projects.

Working as part of our Antibody Engineering team, you will support the antibody humanisation activities as well as any modifications and engineering of antibodies required during the lead optimisation phase.

You will be responsible for assessing the properties of antibody-based molecules with a range of assays and techniques as part of discovery or humanisation campaigns. This will require performing specialised and non-routine experiences as well as analysing and interpreting data and presenting results/conclusions to project leaders and the wider project team.

• Deliver optimised antibodies through humanisation and other engineering strategies
• Use molecular modelling and sequence analysis to design engineered antibody variants.
• Screen antibody variants using high throughput expression and binding studies, including ELISA and binding kinetics.
• Perform and support more detailed analysis of lead antibody panels for detailed binding, function and develop ability criteria
• Provide clear verbal and written reports/presentations internally as required

• Hands‑on experience of developing, setting‑up and using binding assays such as ELISA, or similar biochemical assays, to assess key parameters of antibody‑based molecules
• Practical experience in protein (antibody) expression in mammalian cells
• PhD in a life science or relevant discipline or BSc/MSc degree with relevant substantial laboratory experience in an outcome driven discovery setting
• Experience in an industrial or industry‑like setting
• Working knowledge of antibody discovery strategies, high‑throughput screening methods or biophysical analytical techniques
• Hands‑on experience in other assay technologies such as determining binding kinetics by SPR or related biophysical methods
• Know‑how regarding the examination or modelling of molecular structures
• Understanding of antibody structure and antibody engineering approaches such as Fc engineering

• Focused on the generation of robust data and its clear presentation in verbal and written formats
• Ability to work well with others as a self‑motivated, proactive and adaptable team player
• Organised and meticulous with details and accuracy
• Critical and analytical thinker, displaying intellectual curiosity to embrace opportunities and expand skills with new methods or equipment.

Life Arc is a not‑for‑profit life science organisation, leading the way for change in rare diseases in the UK and supporting promising initiatives in global health. We seek out research in areas of unmet need that has great potential, providing support to help it become breakthroughs that change lives.

Focused on finding life changing solutions for underserved patients, our people thrive in an inclusive, and supportive environment that prioritises their health and wellbeing. Our multidisciplinary approach guarantees our people growth opportunities, while our culture of innovation and collaboration drives the impact we make delivering on our purpose of ‘putting patients at the centre of everything we do’.

Life Arc is committed to making our recruitment practices as inclusive as possible and developing a culture that values differences. As a Disability Confident Employer, we guarantee an interview to candidates with a disability or long‑term health condition who meet the essential criteria for the role.

Please note that in certain situations, such as high volumes of applications, it may not be practical to interview all eligible candidates. In these cases, we may need to select those who best meet the essential criteria. (At Life Arc, the Disability Confident Scheme’s ‘minimum criteria’ is referred to as ‘essential criteria’).

Salary will be determined by qualifications and experience along with other…