Computational Biologist, CRISPR Informatics; Biohub SF

The Chan Zuckerberg Biohub San Francisco (CZ Biohub SF) is an independent nonprofit research institute that brings together three powerhouse universities - Stanford, UC Berkeley, and UC San Francisco - into a single collaborative technology and discovery engine. CZ Biohub SF itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new technologies that will lead to actionable diagnostics and effective therapies.

We are guided by our values of scholarly excellence; disruptive innovation; hands-on engineering/hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.

Our Vision

- We pursue large scientific challenges that cannot be pursued in conventional environments

• We enable individual investigators to pursue their riskiest and most innovative ideas
• The technologies developed at CZ Biohub San Francisco facilitate research by scientists and clinicians at our home institutions and beyond
  
  Diversity of thought, ideas, and perspectives are at the heart of CZ Biohub Network and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.
  
  The Opportunity
  
  We’re a cross-disciplinary institute on an audacious quest: to chart the dynamic architecture of cells at a scale and resolution once thought impossible. By uniting biology, engineering, and computation, we invent the breakthrough technologies this vision demands. Recent innovations from our team include an automated CRISPR experiment design engine that performs comprehensive optimizations while operating at the genome-wide scale. Leveraging such tools, we generated open-source datasets that illuminate the spatial organization of the human proteome in healthy and diseased states.
  
  We’re gearing up for our most ambitious push yet, as our next Computational Biologist you will architect and build the computational backbone that powers our upcoming large scale CRISPR experiments in both human cells, organoids and even whole organisms (zebrafish). These studies will span precise knock-in/out, high-content image-based CRISPR screening and programmable expression control—converting diverse perturbation datasets into systematic biological insights.
  
  Join us in San Francisco (with a planned move to Redwood City in two years) and drive the next wave of methodological innovation and scientific discovery that will redefine how dynamic cellular systems are decoded.
  
  This role will be based in San Francisco initially, with a planned transition to Redwood City in two years.
  
  You will
  
  - Architect, build and maintain computation workflows for CRISPR design and edit-outcome analysis.
• Analyze genome-scale CRISPR perturbation datasets and identify emergent gene-function and pathway networks.
• Work with molecular biologists, imaging scientists, and software engineers to plan large scale CRISPR experiments and interpret results.
• Package, document and rigorously test code, computational pipelines and datasets for open-source release.
• Author publications and present research findings at conferences.
  
  You have
  
  Essential –
  
  - Ph.D. in Computational Biology, Bioinformatics, Bioengineering, Genomics or a related discipline. Candidates with a master’s degree and 3 years of relevant experience will be considered.
• 2+ years of deep, current knowledge of CRISPR genome-engineering technologies (e.g. CRISPRi/a, base/prime editing, CRISPR-based imaging) and the underlying molecular biology.
• Proven track record of developing computational pipelines for CRISPR design and edit-outcome analysis.
• Fluency in Python (or similar), experience with workflow management frameworks (e.g., Nextflow, Snakemake), and strong software engineering practices including testing, continuous integration, documentation, and version control.
• A collaborative, team-focused mindset coupled with outstanding communication skills.
  
  Nice to have
  - - Experience in…