Principal Scientist - Medicinal Chemistry

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award‑winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Let’s do this. Let’s change the world. In this vital role you will part of an innovative Medicinal Chemistry group, with responsibilities including (but not limited to) the design, synthesis, and purification of novel compounds for potential clinical drug development. This will also include the opportunity to work within Amgen’s Induced Proximity Platform (IPP), which is focused on novel and innovative approaches to modulate intractable targets in diseases using the emerging PROTAC modality.

This is an onsite laboratory position at our South San Francisco site.

• Devise and implement state of the art scientific research through conducting laboratory experiments, planning detailed procedures for defined projects including timelines, milestones, methodological approaches, expected results and necessary resources
• Review, analyze, and interpret scientific data and results; providing regular updates, documentation, and/or communication on project results; collaborating with other scientists and keeping current with field of expertise, including literature and technology development.
• Additional responsibilities may include advising supervisors and colleagues in areas of expertise; participating in national and international meetings, providing scientific results that support the generation of publications or patents, and mentoring research associates and laboratory assistants.

We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a Principal Scientist with these qualifications.

Basic Qualifications:

Doctorate degree and 2 years of scientific experience or

Master’s degree and 5 years of scientific experience or

Bachelor’s degree and 7 years of scientific experience

Preferred Qualifications:

• Doctorate degree in chemistry specializing in organic chemistry and 6+ years of experience in synthetic organic and medicinal chemistry
• Experience leading medicinal chemistry teams and delivering candidates for clinical development
• Extensive track record of consistent and successful drug discovery accomplishments (e.g. patent inventor-ship, conference presentations, and peer‑reviewed publications)
• Deep understanding of drug discovery and relevant drug discovery disciplines (e.g. chemistry, biology, safety, PKDM, etc.)
• Expert in modern medicinal and synthetic chemistry approaches
• Excellent collaboration and communication skills (both written and oral)

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well‑being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement…