Associate Scientist, Bioassay Development

Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases. The Associate Scientist, Bioassay Development role will support the development of state‑of‑the‑art potency assays for our diverse pipeline of large‑molecule biotherapeutics, including antibodies, Fc‑fusion proteins, oligonucleotide‑conjugates, and virus‑based gene therapies.

• Independently perform bioassays to support cell and plate‑based (ELISA, enzyme activity) development for late‑stage molecules.
• Assist in the development, optimization, and qualification of assays for product release, stability testing, and characterization of biological activity.
• Support study sample testing and analysis, maintain complete and accurate records, and contribute to continuous process improvement.
• Evaluate, characterize, and document critical reagents to meet QC standards.
• Coordinate parallel tasks across multiple projects and prioritize deliverables to meet departmental and organizational goals.
• Promote innovation and explore novel analytical techniques or technologies.

• BS with 3+ years of industry experience or an MS with 1+ year of relevant industry experience.
• Experience in developing and optimizing bioassays using cell‑based assays, ELISA, HTRF, enzyme activity, enzyme kinetics, and Octet.
• Proficient in aseptic technique, and mammalian and primary cell handling.
• Proficient in data analysis with Excel and statistical tools such as Graph Pad Prism, Soft Max Pro, and PLA 3.0.
• Familiar with electronic notebooks and documentation workflows.
• Ability to balance competing priorities and thrive in a dynamic, fast‑paced environment.
• Excellent laboratory, critical‑thinking, scientific problem‑solving, and organizational skills.
• Excellent oral and written communication skills.
• Motivated, detail‑oriented, naturally curious, with a creative approach to scientific problem solving and a burning desire to help patients with neurodegenerative diseases.

Salary Range: $ to $. Compensation for the role will depend on a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401(k), healthcare coverage, ESPP, and a broad range of other benefits.

Denali is committed to creating a diverse and inclusive environment. We are a proud equal‑opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, veteran status, basis of disability, or any other federal, state, or local protected class.

San Francisco, CA