Postdoctoral Position in Peptide & Medicinal Chemistry
Listed on 2026-02-01
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Research/Development
Research Scientist, Data Scientist -
Healthcare
Data Scientist
Florida Atlantic University (FAU) – Roche Research Group
The Roche Research Group at Florida Atlantic University is seeking a highly motivated Postdoctoral Fellow to join an interdisciplinary research program focused on developing next-generation peptide therapeutics targeting protein–protein interactions (PPIs) in inflammatory disease.
This Leo Foundation–supported project leverages the ADAPT platform, a novel technology that converts antibody CDR-H3 loops into β-hairpin peptide mimetics with antibody-like specificity and improved pharmacokinetic properties. The primary biological focus is the inhibition of IL-17 and IL-23 signaling pathways relevant to psoriasis (I&I).
Responsibilities- Design, synthesize, and characterize CDR-H3–mimetic β-hairpin peptides using solid-phase peptide synthesis (SPPS)
- Develop and screen non-covalent and covalent peptide libraries
- Perform peptide folding and stability analyses (CD spectroscopy, VT-CD)
- Conduct structural studies by NMR spectroscopy
- Collaborate on biochemical, cellular, and in vivo validation studies (ELISA, keratinocyte assays, murine psoriasis models)
- Analyze and integrate chemical, biophysical, and biological data for publication
- Contribute to manuscripts, grant reports, and collaborative discussions
Duration:
Up to 3 years
Salary: $62,000 per year plus full benefits
Start Date:
Preferably March-April 2026
The successful candidate will work in a well-equipped laboratory environment and interact closely with collaborators at the Miller School of Medicine at the University of Miami, the University of Colorado, and UF-Scripps for biological and pharmacokinetic studies.
To apply:
Please submit a CV, brief statement of research interests, and contact information for 2–3 references to Dr. Stephane Roche (sroche2).
- Ph.D. in Chemistry, Medicinal Chemistry, Chemical Biology, or a closely related field
- Strong background in synthetic organic or peptide chemistry
- Experience with SPPS and peptide purification (HPLC, LC-MS)
- Ability to work independently while contributing to a collaborative research team
- Experience with peptide secondary structure analysis (CD, NMR)
- Familiarity with covalent inhibitors or protein–protein interaction modulators
- Interest in translational research and drug discovery
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