Associate Scientist, Cell Line Development

Associate Scientist, Cell Line Development page is loaded## Associate Scientist, Cell Line Development locations:
South San Francisco time type:
Full time posted on:
Posted Todayjob requisition :
R-1453

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

We are looking for a highly motivated and collaborative scientist to join our Bioprocess Development team, focused on cell line development (CLD). The successful candidate will be joining a multidisciplinary team to generate commercially viable cell lines for novel and complex therapeutic molecules including bispecific antibodies, Fc fusion proteins, and enzyme fusions.

Key Responsibilities  
* Support the development of Denali’s mammalian biotherapeutic production platform to  generate commercially viable cell lines.
* Execute cell line development activities including transfection, selection, single cell  sorting, clone imaging, clone selection, and clone banking for pipeline projects.
* Design, execute, and interpret cell line development experiments in collaboration with  other scientists in the group, including the use of JMP statistical software for DOE  experiments and generating figures.
* Write technical and summary reports including cell line development reports which  serve as source documents for regulatory filings, effectively communicate findings with  cross-functional teams, and participate in scientific discussions with scientific teams.
* Maintain accurate and detailed laboratory notebook and relevant documentation.  ∙ Cross-functionally support cell culture process development through bioreactor  production runs and DOE-based screening experiments as necessary.
* Evaluate, optimize, and implement characterization assays such qPCR, Western blots,  and flow cytometry.

Requirements  
* BA/BS or MS degree in Molecular Biology/Biochemistry/Cell Biology or related field  ∙ Technical proficiency in mammalian cell culture and upstream process development  preferably in an industrial laboratory
* 2+ years of experience working in a laboratory environment
* Experience in CHO cell line development for biologics preferred
* Proficiency with protein characterization techniques such as Octet, SDS-PAGE, Caliper,  and HPLC
* Demonstrated ability to organize, analyze, and interpret experimental data, specifically  in JMP and Excel
* Ability to work effectively and collaboratively with other scientists in cross-functional  project teams
* Excellent oral presentation and written communication skills

Salary Range: $ to $ .  Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at  compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.“Life

at Denali” is a living reflection of our values: trust, unity, grit and growth. These are not just words we share—they shape how we show up, collaborate and push boundaries together. From the lab to the community, across functions and milestones, our culture thrives on shared purpose and relentless pursuit.
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