Research Associate II, Biologics

Lycia Therapeutics is a biotechnology company using its proprietary lysosomal targeting chimera (LYTAC) platform to discover and develop best‑in‑class therapeutics that degrade extracellular and membrane‑bound proteins. These proteins drive a wide range of difficult‑to‑treat diseases, including autoimmune and inflammatory conditions. Lycia was established in 2019 in collaboration with academic founder and Nobel Laureate Carolyn Bertozzi, Ph.D., professor of chemistry and HHMI investigator at Stanford University.

In May 2024, Lycia Therapeutics completed a $106.6 million Series C financing to advance its pipeline of LYTAC extracellular protein degraders to the clinic. Lycia is headquartered in South San Francisco.

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Lycia Therapeutics is seeking a highly motivated and detail‑oriented Research Associate II to join the Biologics team. The successful candidate will be responsible for the generation and characterization of molecules to support early discovery research efforts. This individual will work cross‑functionally as part of an innovative research organization to help advance molecules to the clinic. Hands‑on experience with protein purification and characterization techniques is required.

• Conduct protein characterization using SDS‑PAGE, HPLC, LC/MS, DLS, and other biophysical/analytical methods.
• Generate bispecific antibodies through controlled Fab‑arm exchange (cFAE).
• Execute secondary protein purification (IEX, SEC, HIC) when necessary.
• Biotinylation and fluorescent dye conjugation of antibodies and proteins.
• Conduct biolayer interferometry (BLI) assays to evaluate antibody‑protein interactions.
• Prepare solutions for binding assessments and in‑vivo studies through formulation and concentration adjustment.
• Update and maintain protein inventories as well as accurate and timely documentation of experimental work in electronic laboratory notebooks (ELNs).
• Contribute to troubleshooting processes, data analysis, and interpretation.
• Opportunity to represent functional area through presentation of data during research team meetings or broader company‑wide meetings.
• Conduct routine maintenance, calibration, and troubleshooting of laboratory instruments as needed.

• BS in Biology, Biochemistry, or related field with at least 2+ years of relevant experience OR MS with 0+ years of relevant experience. Previous industry experience is strongly preferred.
• Proficiency with FPLC systems (e.g., AKTA) and associated software (e.g., Unicorn).
• Experience in characterizing recombinant proteins, particularly monoclonal/bispecific antibodies, and associated analytical techniques (SDS‑PAGE, HPLC, LC/MS, DLS, BLI).
• Basic understanding of protein conjugation technologies (NHS chemistry, enzymatic conjugation, fluorescent dye labeling) and related QC is a plus.
• Demonstrates strong organizational skills and meticulous attention to detail to manage experimental workflows, while effectively communicating findings across multidisciplinary teams.
• Ability to work both independently and collaboratively in a team‑oriented research environment.

The expected base salary range for this role is $95,000-$105,000. We encourage candidates of all levels to apply as there is often flexibility on job title and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications, and internal equity. Lycia offers a competitive employment package that includes an annual bonus, equity, and a generous benefits package.

We are an equal‑opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Lycia and other biotech companies have recently noticed an increase in email and social media scams targeting job candidates in our industry. Please note Lycia will post any legitimate job openings directly on our website or through our recruitment partner, Lever. If you wish to verify the legitimacy of a job opening, you may contact us.