Senior Director, Global HEOR and Evidence Generation

Locations:

Type:

Full time

Req#:

2290

Encoded Therapeutics is a biotechnology company combining the precision of gene regulation with the versatility of gene therapies to create breakthrough treatments for individuals living with severe genetic diseases. For more information, please visit  .

Reporting to the VP Medical Affairs, the Senior Director, Global HEOR and Evidence Generation is a senior member of the Medical and Patient Affairs (MPA) team who will serve as a critical cross-functional bridge to support regulatory and commercial evidence generation needs. This individual will be the primary architect and owner of the HEOR and value evidence strategy for ETX
101, the first gene therapy for Dravet syndrome.

ETX
101 is a single-administration, potentially transformative intervention. As such, this individual understands global evidence needs and will be responsible for developing a sophisticated, long-term value evidence package for global stakeholders, and for designing and implementing effective solutions that optimize value and access discussions. This is a high-impact role for an individual who thrives on translating vision into execution within a fast-evolving and innovative environment.

Responsibilities:

• Strategic planning and implementation:
  Define and lead the global HEOR roadmap for ETX
  101, ensuring that strategies drive creation of a strong value story for ETX
  101 to optimize payer and HTA engagement in alignment with clinical, regulatory and commercial readiness timelines and plans.
• Integrated evidence generation:
  Serve as a key internal expert supporting design of Encoded’s clinical development program to maximize their utility both for regulatory authorities and payers. Design and execute specific studies, including burden-of-illness (BOI; clinical, humanistic, economic), real-world evidence, and patient preference studies. Support development and/or validation of clinically meaningful outcome measures. Oversee development of cost-utility analyses and budget impact modelling.
• Stakeholder engagement:
  Partner with clinical experts, the patient community, HTA bodies/payers, and other external collaborators to disseminate accurate information across channels, including publications, congresses, and symposia.
• Operational excellence:
  Manage vendor selection, budgets, and resource allocation for complex HEOR projects, ensuring timely completion and, in concert with Scientific Communications, high-impact delivery of abstracts, posters, and manuscripts.
• Cross-functional support:
  Contribute to or lead other cross-functional initiatives, as needed, including Medical Affairs, Market Access and Commercial activities (e.g. payer/HTA research, value messaging, launch roadmaps, and CoE and patient journey mapping) to ensure development of innovative approaches that address the unique opportunities and challenges of gene therapy.
• Travel domestically and internationally, as required.

Requirements

• Education:
  
  PhD, Pharm
  
  D, or MD with 10–12+ years of experience in HEOR within the biotech/pharma industry.
• Deep technical knowledge of the unique value drivers for high-cost, one-time therapies and the global HTA landscape (e.g., ICER, NICE, G-BA, JCA).
• Understanding of medical terminology, statistical concepts, and the ability to oversee complex observational research studies and cost-effectiveness modelling.
• Exceptional written and verbal communication skills, capable of presenting technical data to payers, investors, and clinical experts.
• Strong project management, and proven success managing multiple complex projects simultaneously in a fast-paced environment
• Direct experience of identifying and managing consultants, agencies, or other vendors
• Excellent written and verbal communication, negotiation, and presentation skills
• Strong interpersonal skills and ability to communicate across all levels of the organization
• Familiarity with gene therapy, rare diseases, or CNS indications preferred
• Proven understanding of medical terminology and statistical concepts

Preferred Qualifications:

• Proven success in a startup environment, with the ability to build functions from the ground…