Director, Toxicology

Overview

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

• Design and implement nonclinical toxicology programs and strategies to evaluate the safety of Denali's therapeutic candidates.
• Conduct and oversee non-GLP and GLP toxicology studies, ensuring adherence to regulatory standards.
• Analyze, interpret, and summarize toxicology data to support safety evaluations.
• Prepare and present safety data to internal project teams and senior management, contributing to informed decision-making.
• Assist in the preparation and authoring of regulatory documents related to nonclinical safety assessments.
• Ensure compliance with relevant regulatory guidelines and standards throughout all stages of toxicology studies.
• Work closely with colleagues in Research and Development, providing toxicology expertise to support cross-functional project teams.
• Participate in project meetings, offering insights and recommendations to advance safety assessment strategies.
• Support investigative efforts into mechanisms of toxicity and contribute to the development of safer therapeutic candidates.
• Assist in developing and implementing de-risking strategies for drug discovery and development projects.
• Lead direct report(s) through annual goal setting, growth planning, adherence to company policies, maintain training compliance and provide ongoing feedback on growth, development and areas of improvement.

• PhD in Toxicology, Biology, Pharmacology or related scientific discipline
• 7+ years of industry (biotech/pharmaceutical drug discovery/development) and/or related experience required; 5+ years of people management/coaching/mentorship required
• Experience with biologics and oligonucleotides preferred
• Strong scientific background and scientific aptitude
• Excellent critical thinking and scientific skills
• Ability to work effectively and collaboratively on cross-functional project teams, and demonstrated can-do attitude
• Ability to work in a fast-paced environment
• Excellent oral, presentation, and written communication skills

Salary Range: $ to $. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at

This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.