Associate Scientist, Cell Line Development

Overview

Denali Therapeutics is a biotechnology company focused on developing breakthrough therapies for neurodegenerative diseases through degeneration biology and translational medicine. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

We are looking for a highly motivated and collaborative scientist to join our Bioprocess Development team, focused on cell line development (CLD). The successful candidate will join a multidisciplinary team to generate commercially viable cell lines for complex therapeutic molecules including bispecific antibodies, Fc fusion proteins, and enzyme fusions.

• Support the development of Denali’s mammalian biotherapeutic production platform to generate commercially viable cell lines.
• Execute cell line development activities including transfection, selection, single cell sorting, clone imaging, clone selection, and clone banking for pipeline projects.
• Design, execute, and interpret cell line development experiments in collaboration with other scientists in the group, including the use of JMP statistical software for DOE experiments and generating figures.
• Write technical and summary reports including cell line development reports which serve as source documents for regulatory filings, effectively communicate findings with cross-functional teams, and participate in scientific discussions with scientific teams.
• Maintain accurate and detailed laboratory notebooks and relevant documentation. Cross-functionally support cell culture process development through bioreactor production runs and DOE-based screening experiments as necessary.
• Evaluate, optimize, and implement characterization assays such as qPCR, Western blots, and flow cytometry.

• BA/BS or MS degree in Molecular Biology/Biochemistry/Cell Biology or related field;
  Technical proficiency in mammalian cell culture and upstream process development preferably in an industrial laboratory.
• 2+ years of experience working in a laboratory environment.
• Experience in CHO cell line development for biologics preferred.
• Proficiency with protein characterization techniques such as Octet, SDS-PAGE, Caliper, and HPLC.
• Demonstrated ability to organize, analyze, and interpret experimental data, specifically in JMP and Excel.
• Ability to work effectively and collaboratively with other scientists in cross-functional project teams.
• Excellent oral presentation and written communication skills.

Salary Range: $ to $. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at

This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.