Scientist, Oligonucleotide Analytical Development

Scientist, Oligonucleotide Analytical Development

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

This position will carry out oligonucleotide analytical development to support our Oligonucleotide Transport Vehicle (OTV) platform, contributing to several programs and positioning us for the future as our groundbreaking OTV therapeutics enter the clinical phase.

• Design, execute, and interpret stability‑indicating chromatographic methods for ASOs/siRNA.
• Develop and apply complementary characterization techniques for ASOs/siRNA, including UV–Vis spectroscopy, mass spectrometry, NMR, Karl Fischer titration, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and circular dichroism (CD).
• Analyze and interpret results, leveraging knowledge of oligonucleotide synthesis and purification processes to understand impurity profiles.
• Transfer analytical methods and manage activities at partner CDMOs, as needed (travel may be required).
• Author and/or review analytical data, specifications, Certificates of Analysis, and method validation protocols and reports.
• Collaborate with discovery scientists, process chemists, quality, and project teams to advance our portfolio and analytical strategies and ensure timely flow of information.
• Experience with modern artificial intelligence or machine‑learning approaches to support chemistry workflows is a plus.
• Perform other responsibilities as needed.

• M.Sc./B.Sc. with 5+ years of relevant experience, with a record of scientific leadership and innovation as demonstrated by publications and/or patents.
• Deep understanding of and demonstrated excellence in the analysis of oligonucleotides and their starting materials.
• Expertise in mass spectrometry is expected.
• Knowledge of phase‑appropriate QC/analytics relevant to oligonucleotide analysis.
• Strong written and verbal communication skills.

Salary Range: $ to $. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.