Senior Scientist Integrated Bioanalysis – Immunoassay Specialist

Job Title: Senior Scientist Integrated Bioanalysis Immunoassay Specialist (level

D)

Location: Multiple locations (Sweden & UK)

Discovery Bioanalysis (DxBA) is a global department within Integrated Bioanalysis, Clinical Pharmacology & Safety Sciences, supporting AstraZeneca’s portfolio from early discovery through clinical development. The team applies advanced analytical technologies, including immunoassay, quantitative LC-MS, flow cytometry, multi-omics, and spatial biology to generate high-confidence datasets for decision-making at key project milestones.

Discovery Bioanalysis is responsible for developing and implementing bioanalytical strategies, ensuring robust and reliable data to guide candidate selection and program progression. Working closely with cross‑functional project teams, the group provides comprehensive support across discovery, preclinical, and clinical phases, contributing to the advancement of therapies for complex diseases.

This is an opportunity for a motivated immunoassay expert to join our Integrated Bioanalysis (IBA) team in Cambridge (UK) as a Senior Scientist
.

As part of the Discovery Bioanalysis Team, you will develop and validate bespoke immunoassays to assess pharmacokinetics and target engagement biomarkers across diverse therapeutic modalities. The role involves designing, executing, and transferring complex assays using advanced instrumentation to support discovery, preclinical and clinical studies. You will ensure assays are fit for purpose to meet their intended context of use and will collaborate with internal and external partners, reviewing and analyzing data;

and troubleshooting assay performance. As a Subject Matter Expert, you will be responsible for enhancing the IBA reputation for scientific excellence by presenting at internal and external meetings, and publishing manuscripts.

Alongside the core laboratory role you will have the opportunity as a Discovery Bioanalytical lead to work within a dynamic cross‑functional team in a matrixed environment, defining and executing on tailored & focused project‑specific bioanalytical strategies supporting decision‑making and advancing the pipeline. You will work in close partnership with key stakeholders across the business, input to project strategy and delivery, managing expectations whilst interfacing with experienced and highly skilled bioanalytical scientist colleagues or our partnered labs.

You will have the opportunity to influence decisions from early discovery through late‑stage development and have an immediate and lasting impact to our diverse pipeline.

• PhD or MSc (1–3 years’ experience), or BSc (3+ years’ experience) in immunology, molecular biology, or related field with significant relevant experience.
• Proven expertise as a subject matter expert in ligand‑binding immunoassay techniques (expert level for MSD plus one of: Gyrolab, Simoa, SMC‑Pro, NULISA, Ella).
• Demonstrated experience in leading bioanalytical project strategy.
• Experience developing robust, state‑of‑the‑art assays for bioanalytical characterization of pharmacokinetics in preclinical and clinical studies, including complex large molecule bioanalysis (e.g., multi‑specific antibodies, T cell engagers).
• Expertise in target engagement and occupancy biomarker assay development, including fit‑for‑purpose approaches.
• Demonstrated experience with total and free assay development to support dose modelling.
• Bioanalytical support for non‑GLP IND‑enabling studies, including assay qualification and tech transfer for GxP‑like and GxP studies.
• Ability to independently design, execute, and troubleshoot assays.
• Proficient in data analysis using Softmax Pro and MSD Workbench.
• Maintain high‑quality documentation in electronic lab notebooks and prepare technical reports for regulatory submissions.
• Interpret complex datasets for key project decisions as part of cross‑functional, multi‑platform teams.
• Effective collaboration in a matrix environment and presentation of findings to scientific and management audiences.
• Agile and adaptable, able to manage multiple projects in a fast‑paced setting.
• Strong…