Research Technician

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We have an exciting opportunity in the Division of Clinical Medicine for someone with a passion for disease modelling looking to use their skills in in vivo modelling and drug screening to make an impact on translatable research. Rare connective tissue disorders have a significant impact on patient lives and increasing research on drug screening in in vivo models are improving patient healthcare.

You will join the Balasubramanian lab in Firth Court to investigate specific genes involved in Osteogenesis Imperfecta, as well as other connective tissue disorders, in zebrafish disease models. As this role requires detailed, deep‑phenotyping and molecular analysis, it provides an excellent opportunity to develop your microscopy skills, molecular biology and data/image analysis.

This role offers you the opportunity to multitask projects and contribute to the maintenance of the Balasubramanian Lab to promote productive and efficient high‑quality research. Educated to a Masters level, you will have the commitment and drive to ask hypothesis‑driven questions to better understand disease mechanisms and their impact in Osteogenesis Imperfecta. You will have the potential to publish in journals and present your data at internal research events.

In vivo modelling and microscopy experience is essential, with a genetics and molecular biology background desirable.

• Investigate genes involved in Osteogenesis Imperfecta in a zebrafish model using mutant and transgenic lines.
• Perform skeletal/collagen phenotypic assays and high quality fluorescent imaging to assess disease progression.
• Perform molecular assays (i.e. qPCR) in mutant zebrafish to understand impact of disease on gene expression.
• Maintain breeding stocks of zebrafish.
• Analyse data and present at regular lab meetings.
• Assist with lab maintenance duties.
• Carry out other duties, commensurate with the grade and remit of the post.

Our diverse community of staff and students recognises the unique abilities, backgrounds, and beliefs of all. We foster a culture where everyone feels they belong and is respected. Even if your past experience doesn't match perfectly with this role's criteria, your contribution is valuable, and we encourage you to apply. Please ensure that you reference the application criteria in the application statement when you apply.

Post‑graduate qualification. Masters, in a relevant subject, e.g. molecular biology, genetics (or equivalent relevant experience).

Essential (Application)

Experience with in vivo models, including zebrafish.

Essential (Application/Interview) Experience in microscopy, including fluorescent microscopes.

Essential (Application/Interview) Experience in staining assays for skeletal/collagen development, e.g. Alcian blue and Alizarin red assays.

Desirable (Application/Interview) Ability to organise workload and time management to meet deadlines.

Essential (Application/Interview) Experience and willingness to assist with lab support, e.g. stock maintenance, ordering.

Desirable (Application/Interview) Ability to multitask and handle several projects at once.

Essential (Application/Interview) Ability to present data, with high quality written and verbal skills.

Essential (Application/Interview) Keep high quality, detailed records of experiments and data.

5.1

£27,319 per annum (pro‑rota)

Full‑time

As soon as possible – 31/01/2027

Principal Investigator

Research Associate

https://thebalasu

For informal enquiries about this…