Scientist II or Sr. Scientist, Analytical Development

Using living cells to treat – and sometimes even cure – cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound results have not yet been achieved in patients with solid tumors, representing approximately 90% of all cancers. And for patients with hematologic malignancies, there is a need for next‑generation cell therapies that can deliver increased response rates and longer duration of response.

We are a clinical‑stage company advancing a pipeline of next‑generation CAR T‑cell therapies for patients with solid tumors or hematologic malignancies. Lyell’s product candidates are enhanced with novel technology designed to generate T cells that resist exhaustion and have qualities of durable stemness in order to drive durable tumor cytotoxicity and achieve consistent and long‑lasting clinical response. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T‑cell biology and its interaction with cancer.

In our quest to advance next‑generation CAR T‑cell therapies, we have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency.

The Scientist II or Sr Scientist, Analytical Development (AD) will be responsible for leading a newly formed product characterization team within Analytical Development. The role and responsibilities would include but are not limited to characterizing drug products from Lyell’s manufacturing facility using flowcytometry, cell based and molecular methods to facilitate manufacturing success, process improvement, immunological interpretations and driving clinical correlations. The successful candidate will be responsible for leading the team and open to hands‑on bench work.

The role will encompass driving projects across various Lyell programs in close collaboration across Tech Ops, Research, Translational and Biometrics teams. The Scientist in this role will work closely with other members of the AD group to support development of characterization assays and transfer them to the product characterization team, mentor team members, review data, maintain high quality ELNs and contribute to IND filings.

The successful candidate will have expertise in cellular immunology, flowcytometry, cell-based and molecular assays with analytical testing methodologies and an understanding of the technological requirements to execute on testing and characterization needs of a cellular therapy company.

• Design, develop, execute, and document flow cytometry/cell/molecular based analytical methods for product characterization and investigations.
• Support product characterization activities, including comparability assessments in support of product life cycle management.
• Partner in the transfer of qualified assays within AD and to QC, and support assay validation and investigations.
• Develop and deliver scientific presentations, prepare clear and concise technical reports, participate in project teams as needed.
• Participate in the evaluation of new analytical technologies and their implementation.
• Provide analytical support to cross‑functional project teams.
• Revise, review, and author assay standard operating procedures and ELNs.
• Contribute to building a culture that encourages continuous learning, improvement, and innovation, and encourages team members to expand their technical skill base.

• Scientist II - A minimum of 11 years of experience in immunology / cell biology, plus a Bachelors or 9 years of experience plus a Masters degree.
• Sr. Scientist I - A minimum of 10 years of extensive experience in immunology/ cell biology, plus a Phd.
• Previous people management experience preferred.
• Well versed in wide variety of analytical techniques such as cytotoxicity assays, flowcytometry, cytokine release assays, cell…