Postdoctoral Fellow - Pavel-Dinu Lab
Listed on 2026-01-13
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Research/Development
Research Scientist, Clinical Research, Immunology Research
Pavel-Dinu Laboratory, Center for Immunity and Immunotherapies (CIIT) Seattle Children’s Research Institute (SCRI) Full-Time | Regular | Day Shift
POSITION SUMMARYThe Pavel-Dinu Laboratory at Seattle Children’s Research Institute is seeking a highly motivated and talented Postdoctoral Research Fellow to investigate how metabolic stress and inflammation alter the function of hematopoietic stem and immune cells in mouse disease models and primary human systems. Our research focuses on defining how metabolic collapse, redox imbalance, and inflammatory signaling impair stem cell function, and how targeted metabolic interventions can restore immune tolerance and regeneration in pediatric immune and metabolic diseases.
The fellow will lead metabolomics-driven projects using both in vitro and in vivo LC–MS, working with primary mouse and human stem and immune cells, and will collaborate closely with metabolomics groups across Fred Hutch Cancer Center. A third research direction offers the opportunity to launch a new project exploring lipid-mediated crosstalk between hematopoietic stem cells and rare immune populations.
This position is ideal for a driven, career-focused scientist who is pursuing an academic trajectory, thrives in a fast-paced, intellectually rigorous, early-stage lab environment, and seeks to develop an independent mechanistic niche in immunometabolism and stem cell biology. The Pavel-Dinu Lab is in an exciting growth phase, and the ideal candidate will have the opportunity to advance emerging research directions while building an independent scientific niche.
The position offers the opportunity for multi-year training and renewal contingent on performance, mutual interest, and funding availability.
- Examine how nutrient availability, redox balance, and metabolic stress influence fundamental states and functional properties of primary human hematopoietic stem cells.
- Apply targeted and untargeted LC–MS metabolomics, stable isotope tracing, and complementary metabolic assays to interrogate bioenergetic and redox pathway dynamics under defined perturbations.
- Use mouse models to investigate how inflammatory and environmental stressors reshape metabolic programs within the hematopoietic compartment in vivo.
- Integrate in vivo metabolomics with functional readouts and immune microenvironment profiling to define metabolic features associated with distinct stress‑adapted states.
- Investigate metabolite- and lipid-associated signaling processes at the interface of immune and hematopoietic cell populations.
- Apply metabolomics-based approaches to characterize metabolic and lipid signaling features across distinct cellular compartments.
- Work at the interface of metabolomics, stem cell biology, genome engineering, and immunology in a dynamic, early-stage research group.
- Access state-of-the-art LC–MS, flow cytometry, single-cell platforms, and in vivo metabolomics resources through SCRI and the broader Seattle research community.
- Collaborate with metabolomics experts across the Fred Hutch Cancer Center.
- Receive direct PI mentorship focused on scientific independence, high-impact publications, academic career development, and competitive fellowship applications.
- Mentor junior scientists and contribute to a collaborative, ambitious, high-performing lab culture.
- Conduct research in a strong institutional environment with a pediatric focus and translational relevance.
- This position is designed for candidates seeking sustained, in-depth training through multi-year mechanistic projects rather than short-term appointments.
- Design, optimize, and execute experiments involving LC–MS metabolomics, metabolic flux assays (in vitro and in vivo), and metabolic perturbation approaches in primary mouse and human stem and immune cells.
- Demonstrate proficiency with mouse models, including handling, dosing/injections, harvesting, tissue processing, transplantation, and…
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