Principal Mechanical Engineer II, Early Research and Development

Job Description

Our Systems Technology Group is focused on creating and advancing technologies to significantly enhance DNA sequencing workflows. We are seeking a Principal Mechanical Engineer to lead the mechanical design, development, characterization, and integration of cutting‑edge sequencing systems.

• Lead end‑to‑end mechanical design and development of mechanical sub‑systems including electro‑mechanical, pneumatic, fluidic, and thermal components.
• Collaborate with engineers from other disciplines (electrical, consumables, materials) to define and manage all critical technical interfaces for your module.
• Develop novel mechanisms for automated reagent and flow‑cell loading, clamping, and sealing, ensuring reliability over repeated use.
• Architect and design thermal control systems, including specification and integration of heating/cooling elements, sensors, condensation control, and heat management.
• Partner with internal and external simulation experts to guide and validate CFD, thermal, and optical models, using empirical data to refine designs.
• Serve as the primary technical expert for your sub‑system during integration, verification, and troubleshooting activities, working directly with the Systems Integration team.
• Lead cross‑functional design reviews, driving alignment and resolving technical trade‑offs between mechanical design, consumables, materials, and assay requirements.
• Drive the technical execution for sub‑systems, manage timelines for your design deliverables, and contribute to the overall project plan.
• Create and maintain all design documentation for your sub‑systems, including detailed CAD models, drawings, and specifications.
• Contribute to the technical strategy for the future integrated system, providing data‑driven recommendations on architecture and technology choices based on your sub‑system's performance.
• Present technical progress, data, and design trade‑offs to the broader project team and key stakeholders, clearly articulating the rationale and impact of engineering decisions.

• PhD in Mechanical Engineering, Bioengineering, or a related discipline with at least 3 years of relevant industry experience; or a Master’s degree with at least 4 years of relevant industry experience; or a Bachelor’s degree with at least 7 years of relevant industry experience.
• Demonstrated deep, hands‑on expertise in the design, development, and testing of complex mechanical, electro‑mechanical, and pneumatic systems, preferably for life science or diagnostic instrumentation.
• Hands‑on expertise in thermal management and the design of precision temperature control systems.
• Experience developing fluidics systems and their interfaces including pumps, valves, tubing, sensors, and material selection.
• Strong proficiency in 3D CAD software (e.g., Solid Works) for detailed design and the creation of manufacturing drawings.
• Expertise designing components for a variety of manufacturing processes (e.g., machining, injection molding, 3D printing).
• Creative and resourceful problem‑solver with the ability to troubleshoot complex issues at the interface of hardware, software, and chemistry.
• Proficient with common machine shop tools, test and measurement equipment, rapid prototyping technology such as 3D printers, laser cutters, CNC mills/lathes, etc.
• Demonstrated proficiency with Python, LabVIEW, or similar tools for device control and data acquisition.

• Demonstrated ability to lead technical projects and mentor junior engineers, providing clear guidance and delegating tasks to achieve project goals.
• Experience using simulation tools (CFD, FEA) to guide design decisions.
• Previous work on the development of next‑generation sequencing (NGS) or other genomics instrumentation.
• Experience working in a regulated product development environment.
• Strong interpersonal and communication skills with the ability to communicate technical knowledge in a clear and understandable manner, especially to non‑experts; excels at problem‑solving under ambiguous situations.
• Excellent organizational skills, including the ability to efficiently evaluate, prioritize and handle multiple changing projects and priorities; completes work in a timely, accurate, and thorough manner.

Pay ranges between 65–80/hr based on experience.

The Planet Group of Companies is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.