Principal Mechanical Engineer

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Start date:

Mid April

Job Posting Title

Principal Mechanical Engineer III, Early Research and Development

Our Systems Technology Group, a part of clients Sequencing Solutions, is focused on creating and advancing technologies to significantly enhance DNA sequencing workflows. We are seeking a Principal Mechanical Engineer to lead the mechanical design, development, characterization, and integration of cutting‑edge sequencing systems. This is a hands‑on role for a multidisciplinary expert focused on solving the core mechanical challenges at the heart of our next‑generation platforms.

You will be responsible for concepting, designing, building, and testing novel electro‑mechanical, pneumatic, thermal, and fluidic solutions that ensure the ultimate performance, reliability, and longevity of our systems. The Principal Mechanical Engineer will play a vital role in driving innovation for our next‑generation instrumentation. We are looking for someone that exhibits a high degree of motivation, independence, and resourcefulness to help us develop solutions to novel DNA Sequencing and automation challenges in a fast‑paced and collaborative environment.

• You will lead the end-to-end mechanical design and development of mechanical sub‑systems including electro‑mechanical, pneumatic, fluidic, and thermal components.
• You will collaborate with engineers from other disciplines (electrical, consumables, materials) to define and manage all critical technical interfaces for your module.
• You will develop novel mechanisms for automated reagent and flow cell loading, clamping, and sealing, ensuring reliability over repeated use.
• You will architect and design thermal control systems, including the specification and integration of heating/cooling elements, sensors, condensation control, and heat management.
• You will partner with internal and external simulation experts to guide and validate CFD, thermal, and optical models, using empirical data to refine designs.
• You will serve as the primary technical expert for your sub‑system during integration, verification, and troubleshooting activities, working directly with the Systems Integration team.
• You will lead cross‑functional design reviews, driving alignment and resolving technical trade‑offs between mechanical design, consumables, materials, and assay requirements.
• You will drive the technical execution for sub‑systems, manage timelines for your design deliverables, and contribute to the overall project plan.
• You will create and maintain all design documentation for your sub‑systems, including detailed CAD models, drawings, and specifications.
• You will contribute to the technical strategy for the future integrated system, providing data‑driven recommendations on architecture and technology choices based on your sub‑system's performance.
• You will present technical progress, data, and design trade‑offs to the broader project team and key stakeholders, clearly articulating the rationale and impact of engineering decisions.

• 5 to 10 years experience as Mechanical Engineer with a BA, Master Degree or PhD in Mechanical Engineering or Bioengineering
• You have demonstrated deep, hands‑on expertise in the design, development, and testing of complex mechanical, electro‑mechanical, and pneumatic systems, preferably for life science or diagnostic instrumentation.
• You have demonstrated hands‑on expertise in thermal management and the design of precision temperature control systems.
• You have experience developing fluidics systems and their interfaces including pumps, valves, tubing, sensors, and material selection.
• You possess strong proficiency in 3D CAD software (e.g., Solid Works) for detailed design and the creation of manufacturing drawings.
• You have expertise designing components for a variety of manufacturing processes (e.g., machining, injection molding, 3D…