Intern, Enzymes and Metabolic Disease Research

Who We Are

Bio Marin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need.

We enlist the best of the best – people with the right technical expertise and a relentless drive to solve real problems – and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we’ve produced a diverse pipeline of commercial, clinical and preclinical candidates that have well‑understood biology and provide an opportunity to be first‑to‑market or offer a substantial benefit over existing therapeutic options.

From research and discovery to post‑market clinical development, our R&D engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first‑in‑class and best‑in‑class therapeutics that provide meaningful advances to patients who live with rare diseases.

The Bio Marin Summer Internship Program will enable students to gain valuable experience and knowledge of the processes and systems within Bio Marin, while gaining an insight into the pharmaceutical/biotech industry. Over the course of 10‑12 weeks our interns gain industry experience while working alongside our talented team on meaningful projects.

The Enzyme and Metabolic Disease (EMD) Group at Bio Marin is dedicated to advancing the understanding and treatment of genetic diseases. Our team focuses on researching the cellular mechanisms underlying these conditions and developing potential therapeutic strategies. We utilize advanced techniques and collaborate across various disciplines to drive innovation in research.

As an intern in the Enzyme and Metabolic Disease Group, you will have the opportunity to work collaboratively on several research projects within Bio Marin’s pipeline. Responsibilities include conducting cell culture experiments involving the generation, maintenance, and characterization of mammalian cell lines expressing reporter transgenes. Cell line characterization approaches will include flow cytometry, PCR, qPCR, Western blotting, immunofluorescence, and luminescence assays.

The candidate will also assist in data analysis, presenting findings to the team, and preparing reports to document research progress.

• Cell Culture: Experience culturing and maintaining a variety of cell lines, including cell line transduction using lentiviral vectors.
• Immunostaining, Flow Cytometry and Microscopy: Proficiency with immunostaining protocols, flow cytometry, and confocal microscopy.
• Data Analysis: Competence in evaluating experimental data utilizing tools such as Microsoft Excel, Graph Pad Prism, or equivalent software.
• Literature Review: Demonstrated ability to conduct thorough literature reviews to contextualize current research and identify gaps in knowledge.
• Experimental Design: Experience in designing rigorous experiments to assess the impact of investigational molecules on gene expression and protein function.
• Scientific Reporting: Ability to prepare detailed reports summarizing experimental outcomes and their broader scientific implications.

• Knowledge of Cell Biology and Genetics: Understanding of gene regulation mechanisms and the effects of genetic mutations.
• Molecular Biology Techniques: Familiarity in analytical methods such as luminescence assays, PCR, qPCR, and Western blotting for gene expression and protein quantification.
• Team
  
  Collaboration:
  
  Proven capability to collaborate effectively with cross‑functional groups, including marketing, IT, and customer service.
• Presentation
  
  Skills:
  
  Advanced skills in presenting research findings to stakeholders and in…