Senior RA​/Associate Scientist

If you’re a Senior Research Associate or Associate Scientist with hands‑on antibody discovery experience and a drive to advance new therapeutics, we’d love to hear from you!

Join Us at Oxford Biotherapeutics (OBT)

Oxford Biotherapeutics (OBT) is a clinical‑stage biotechnology company developing innovative antibody‑based therapeutics for the treatment of cancer. You will contribute directly to the pre‑clinical development of our immuno‑oncology pipeline.

Our proprietary OGAP® platform, the world’s largest cancer‑specific membrane protein library enables the discovery of novel, highly tumour‑specific antigens for first‑in‑class ADC, Bispecific T‑cell Engager (BITE®), and CAR‑based therapeutics. Our lead asset, OBT
076, is in Phase 1b clinical development, supported by a strong internal and partnered pipeline with leaders such as Roche, Boehringer Ingelheim, and Zymeworks.

Learn more at .

The Antibody Discovery Research Associate will support early‑stage therapeutic and tool antibody programs by performing experiments that contribute to antibody generation using single B cell platforms, screening, and lead candidate selection.

The ideal candidate is highly organized, detail‑oriented, and comfortable working in a fast‑paced, collaborative research environment.

• Perform hands on antibody discovery work flows including cell culture, multi colour flow cytometry to sort and analyse rare immune cell populations.
• Develop, optimize and perform screening cell‑based functional assays.
• Characterize antibodies by performing Elisa, SPR, BLI (Octet), Western blot.
• Maintenance of cell lines, freezing, thawing, expansion.
• Perform molecular biology tasks like PCR, cloning, transfection, sequence analysis, RNA/DNA purification methods, gel extraction as needed.
• Ensure all experimental work complies with established protocols and SOP’s.
• Maintain accurate and detailed experimental records and record all experimental data into Electronic Notebook.
• Contribute to troubleshooting, optimization, and continuous improvement of discovery workflows
• Compiling and analysing data by Flow Jo, Graph Pad Prism, and Excel.
• Conduct analysis and effectively communicate results and present data at internal meetings.
• Collaborate with cross functional teams to align with project goals.
• Committed to fostering an inclusive, collaborative, and innovative research environment.

Please note the roles and responsibilities for the position include but are not limited to the above.

• BS. or M.S. in Molecular Biology, Immunology, Bioengineering, Biochemistry, or related field with 5+> years of experience working in a lab setting (industry experience preferred).
• Experience with antibody discovery platforms including single B cell, hybridoma, or display technologies.
• Proficiency in mammalian cell culture, in vitro assay development and flow cytometry.
• Strong organizational skills, attention to detail and ability to work independently and collaboratively.
• The ability to be a team player and collaborate with colleagues is critical.

• Strong understanding of B cell biology.
• Experience working with antibody sequences, including CDR identification and diversity analysis
• Hands‑on experience with multi‑color flow cytometry including panel design, staining, compensation, and data analysis/interpretation
• Hands on experience with BLI or SPR.
• Assay development and characterising antibodies using cell‑based assays and flow cytometry.
• Comfortable working with high‑throughput screening tools or automation.
• Experience with cell engineering technologies, such as transfection, electroporation, lentiviral transduction, and CRISPR.
• Experience with high‑throughput antibody expression & purification.
• Experience with cytotoxicity assays using T cell engagers
• Innovative, detail‑oriented, and quality‑driven with a proactive mindset.
• Exceptional communication and interpersonal skills; able to translate complex data for diverse audiences.
• Highly motivated self‑starter with scientific curiosity and a roll‑up‑your‑sleeves attitude.
• Flexible and eager to learn new methods and optimise workflows.

We care deeply about the wellbeing of…