Research Scientist​/Engr

Overview

Field of research: Single particle cryo-electron microscopy and X-ray crystallization of viral glycoproteins, immunogen design, virology, biochemistry and biophysics.

Purpose of the Research Project(s): The goal of our research is to develop vaccines and therapeutics targeting human pathogens.

• 20% Structure-based and machine-learning immunogen design for protein subunit and mRNA vaccines based on viral surface glycoproteins (construct design, recombinant expression in mammalian cells, purification, and stability assays).
• 20% Characterize protein antigenicity (binding assays using ELISAs, SPR and biolayer interferometry to evaluate binding kinetics and affinity of antibodies or designed proteins).
• 15% Perform structural studies (high-throughput cryo-electron microscopy of subunit vaccines as well as of complexes between viral glycoproteins and monoclonal and polyclonal antibodies as well as X-ray crystallography).
• 10% Design and execution of virology assays.
• 10% Analysis of the data to help determining the research strategy.
• 10% Lead projects and/or major project tasks.
• 10% Interactions with collaborators within our network and writing of manuscripts for publication.
• 5% Provide guidance and direction to project staff, students and postdocs.

Requirements: Master s Degree in Biochemistry or related field and four years of experience in related field such as cryo-electron microscopy, virology assays (pseudo typed virus generation, cellular entry and neutralization assays), protein expression in mammalian cells and purification. Equivalent education and/or experience may substitute for minimum qualifications except when there are legal requirements, such as a license, certification, and/or registration.

Desire: Expertise in protein and vaccine design, experience in high throughput automation using Beckman Biomek.

Pay Range Minimum: $99,444.00 annual

Pay Range Maximum: $ annual

Other Compensation: -

Benefits: For information about benefits for this position, visit https://(Use the "Apply for this Job" box below)./

Shift: First Shift (United States of America)

Temporary or Regular? This is a regular position

FTE (Full-Time Equivalent): 100.00%

Union/Bargaining Unit: UAW Research

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