Director​/Senior Director, Clinical Project Management

Director/Senior Director, Clinical Project Management Position Summary

TCG Labs-Soleil is looking for a Director/Senior Director of Project Management who will report to the Chief Medical Officer. This individual will serve as the operational backbone of multiple development programs, ensuring timely execution, alignment across teams, and delivery of program goals from preclinical through clinical development. The ideal candidate is a proactive and adaptable operator with a proven track record in large molecule drug development, excellent communication skills, and the ability to thrive in a fast-paced, collaborative environment.

• Providing small team of PDT (project development team) PMs, providing technical mentorship and further development
• Will project manage 3-5 PDTs across oncology and non-oncology areas
• Drive the overall planning, execution, and delivery of assigned drug development programs from candidate nomination through early clinical trials.
• Support the Project Team Leader (PTL) on cross-functional Project Development Teams (PDTs), including Clinical, Regulatory, Toxicology, Pharmacology, Assay Development, CMC, Research and Strategy, ensuring clear roles, responsibilities, and accountability.
• Provide operational and planning support to sub teams led by various functions (e.g., Clinical sub team, Reg sub team, Translational sub team)
• Develop and maintain integrated project plans, timelines, milestones and risk assessments
• Is responsible for PDT meeting agenda and notes
• Support decision-making by ensuring team members are informed, risks are managed, and dependencies are clearly understood.
• Manage external collaborators, consultants, and vendors as needed to support program execution.
• Is onsite ≥3 days per week, particularly during PDT meetings

• At least BS in life sciences and a PMP qualification;
  PhD highly preferred
• 10+ years of experience in biotech/pharmaceutical program management, having worked in both Big Pharma and small biotech
• Successful track record of growing, coaching and managing team of PMs for at least 3 years
• Experience in both oncology and non-oncology biologics required. Small molecule experience in addition to biologics is a plus
• Direct experience in early-stage non-oncology projects preferred, or a demonstrated willingness to learn/apply PM skills in non-oncology areas
• Significant direct experience in project management of early-stage (candidate nomination through end of Phase
  2) oncology biologics is mandatory
• Strong understanding of regulatory requirements, clinical trial design, and CMC development
• Track record of collaboratively ensuring cross-functional productivity in a PDT setting and of supporting PTLs
• Understanding of risk management and experience establishing mitigation strategies
• Expertise in the use of modern project management tools (Gantt charts, risk logs) and technologies (Smartsheet’s, Excel, PowerPoint, Think Cell)
• Ability to operate with a sense of urgency and flexibility in a fast-paced, dynamic environment and is comfortable with ambiguity and strategic changes

TCG Labs-Soleil, established in partnership with The Column Group, a science-focused venture capital firm, is pioneering a novel ‘venture capital-biotech’ model. Our core mission is to efficiently translate scientific insights into therapeutic solutions for patients facing serious diseases. This model supports scientific entrepreneurs from the initial idea to clinical proof of concept (PoC) by combining a dedicated fund (TCG Labs) with our independent, evergreen R&D center led by a top-tier scientific team (Soleil).

Together, we create an integrated ecosystem that fosters the development of single-asset portfolio companies, strategically poised for transacting after clinical PoC.
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TCG Labs-Soleil is an Equal Opportunity Employer. We do not discriminate against qualified applicants based upon any protected group status, including but not limited to race, religion, color, creed, sex (including breastfeeding and related conditions), gender identity/gender expression, pregnancy (including childbirth…