Vice President, Clinical Business Operations and Strategy

Vice President, Clinical Business Operations and Strategy

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Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies.

The Vice President, Clinical Business Strategy and Operations serves as a critical strategic partner to the SVP of Clinical Operations and the Development Leadership Team, driving alignment, execution, and operational excellence related to the business operations of our global clinical programs. This role integrates visionary leadership, high-level strategic planning, organizational enablement, fiscal strategy and governance oversight with leadership of the company’s global clinical business operations activities—ensuring that partnerships, vendors, and financial commitments align with scientific and corporate priorities.

The ideal candidate is a seasoned biotech executive who thrives at the intersection of science, strategy, and business operations, with demonstrated expertise in clinical outsourcing, vendor management, cross‑functional execution, strategic planning, clinical finance, project management, business planning & operations, leadership and mentoring, and fostering cross organisational collaboration within high‑growth scaling biotechnology organisations.

• Create long‑term strategic direction for Revolution Medicines’ clinical business operations, ensuring that outsourcing models, vendor partnerships, and financial strategies support the company’s integrated R&D and commercialization goals.
• Serve as trusted advisor and thought partner to leadership to translate the evolving strategic vision of clinical operations and policies into operational execution.
• Create functional alignment with Finance, Legal and Development functions for financial and resource deployment with strategic priorities.
• Lead transformation of outsourcing and business partnership models to drive efficiency of our clinical trial execution in alignment with corporate objectives and growth trajectory.
• Lead the global vendor outsourcing function, responsible for developing, negotiating, and managing agreements with CROs, investigators, clinical sites, and strategic partners.
• Establish standardized contracting frameworks, performance metrics, and SLAs to enhance consistency, speed, and compliance across programmes.
• Design and ope rationalise a scalable operating model to deliver required CTA volumes based on Rev Med needs.
• Identify gaps, aligning building of solutions and drive evaluation, selection, deployment and oversight of clinical outsourcing agreements processes.
• Develop and maintain a vendor governance model that ensures transparency, quality and fiscal responsibility across global partnerships.
• Establish metrics and governance to ensure performance, compliance and fiscal responsibility.
• Implement metrics and dashboards to monitor contracting cycle times, vendor performance and clinical business operations efficiency.
• Establish functional effectiveness by cultivating leadership capability across the CORE team and embedding a values‑driven culture of collaboration, innovation, accountability, growth and strategic foresight.
• Partner with Development Program Management, Business Operations and other functional leaders to develop and implement cross‑functional processes that maximise organisational impact, scalability and compliance with ICH/GCP and global standards.
• Set roadmap for strategic change management across clinical operations, leveraging best practices to ensure successful and sustainable adoption.

• 20+ years of progressive leadership experience in biotechnology or pharmaceuticals, including at least 8 years in clinical outsourcing, contracting or business operations.
• Minimum of 10 years clinical operations systems project and line…