Senior Director, Cancer Immunology

Revolution Medicines is a clinical‑stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS‑addicted cancers. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

This role represents a unique opportunity to serve as a strategic and scientific leader within Cancer Immunology, reporting into the Biology organization. We are seeking a highly motivated, critical thinker with a passion for scientific excellence and innovation, who can drive the discovery and advancement of novel immuno‑oncology targets and modalities. The successful candidate will lead a multidisciplinary team, shape the scientific vision for Discovery Cancer Immunology, and provide oversight of scientific integration across both Discovery and Translational Cancer Immunology.

• Discovery Program Leadership & Strategic Oversight: lead Cancer Immunology discovery programs from project qualification through Development Candidate nomination, drive identification and validation of novel immuno‑oncology targets, ensuring seamless progression into Translational Cancer Immunology.
• Platform & Modality Innovation: oversee development and optimization of experimental platforms, including in vitro and in vivo models, phenotypic screening, and advanced assay toolkits; champion new therapeutic modalities such as TCEs, ADCs, and bispecifics.
• Scientific Integration & Operational Excellence: provide strategic oversight of scientific integration across Discovery and Translational Cancer Immunology, ensuring operational rigor, platform support, and alignment of resources; promote deployment of modern data systems and analytics to advance scientific and operational excellence.
• Cross‑functional
  
  Collaboration:
  
  partner with Research Leadership to support advancement of programs from early discovery into the clinical development portfolio; coordinate discovery efforts, platform capabilities, and translational priorities.
• Team Leadership & Mentorship: lead, mentor, and inspire a multidisciplinary team of PhD and non‑PhD scientists; cultivate a culture of scientific excellence, innovation, and collaboration.
• External Engagement: spearhead collaborations with academic partners and external organizations, define publication strategies, and support the company’s scientific reputation.

• Ph.D. in immunology, cancer biology, or related discipline; deep expertise in tumor immunology, immune‑evasive oncogenic signaling pathways, and/or immunotherapy; proven track record of excellence in research with high‑impact publications.
• Industry experience in oncology drug discovery and development, including antibody‑directed therapies such as T cell engagers, ADCs, or bispecific antibodies; early discovery strategy experience desirable.
• Demonstrated leadership and people‑management skills; experience leading multidisciplinary teams and mentoring scientists.
• Strategic and analytical thinker capable of prioritizing initiatives, anticipating challenges, and executing effectively in a dynamic, high‑energy environment; rigorous, quantitative, detail‑oriented experimentalist.
• Excellent written and verbal communication skills; ability to influence and align diverse stakeholders; thrives in collaborative, interdisciplinary teams.

• Experience with chemistry‑based therapies, including small molecules or ADC payloads.
• Familiarity with bioinformatics‑driven discovery and integrating computational insights into experimental design.
• Proficiency with modern data platforms, machine learning approaches, and advanced analytics for Cancer Immunology research and decision‑making.
• Prior experience as a Program Team Leader, driving cross‑functional strategy and execution across discovery and development stages.

Base pay salary range for this full‑time position, onsite at our headquarters in Redwood City, CA:

• $236,000 — $295,000 USD

Base pay is one part of our overall total rewards program, which includes…