Research Associate, Cell- Assays; LOCAL

Origami Therapeutics, Inc
., a San Diego-based biotech company, is pioneering a groundbreaking approach to target misfolded proteins, the root cause of many diseases, to slow brain aging, prevent neuronal degeneration and extend health span. Our proprietary ORICISION™ platform enables discovery of both protein degraders and protein conformation cor rectors, allowing us to match the best drug to treat each disease using patient‑derived disease models to ensure successful translation into the clinic.

Origami’s lead asset is an oral pill, first‑in‑class protein degrader for Huntington’s disease. Multiple assets for additional indications including Frontotemporal Dementia, Alzheimer’s disease and ALS are being developed.

Origami is seeking a highly motivated individual to contribute to exciting drug discovery programs advancing therapies for neurodegenerative diseases.

The successful candidate is expected to play a key role in the Origami team, should have considerable cell culture experience, and have a strong knowledge of standard biochemical, cell and molecular biology techniques. The individual is expected to have a track record of successfully providing timely, accurate work.

• Perform cell-based assays and maintain cell cultures
• Maintain detailed, accurate experimental protocols and laboratory notebooks
• Analyze data in a timely manner
• Keep accurate inventory of supplies for laboratory operations
• Effectively communicate with team members on research progress
• Perform all other related duties as assigned; level of responsibility will depend on experience

• Bachelor’s degree in relevant scientific field with a minimum 1 year of relevant experience in an industry setting
• Minimum 1 year of hands‑on mammalian cell culture experience
• Hands‑on experience with cell‑based assays, standard biochemical and/or molecular biology techniques.
• Ability to execute experiments accurately, on time, and according to established protocols
• Proficiency with standard laboratory calculations, dilutions and multi‑well plates
• Meticulous and timely record keeping
• Demonstrated ability to multitask and collaborate with scientists in a highly dynamic environment
• Outstanding organizational, time management, verbal and written communication skills

• Cell culture of human primary cells, neurons, stem cells or induced pluripotent stem cells (iPSCs)
• Experience using Quantitative Capillary Western, MSD and/or immunochemistry techniques
• Experience with automation / high throughput assays

Origami offers a dynamic work environment and an attractive salary commensurate with experience. Additionally, Origami offers a comprehensive benefits package which includes Paid Time Off, Holidays, 401(k) plan, Company insurance coverage (Medical, Dental, Vision) and stock options. Origami is an Equal Opportunity Employer.