Scientist, Cell- Assays; LOCAL

Scientist or Senior Scientist, Cell-based Assays

Origami Therapeutics, Inc
., a San Diego-based biotech company, is pioneering a groundbreaking approach to target misfolded proteins, the root cause of many diseases, to slow brain aging, prevent neuronal degeneration and extend health span. Our proprietary ORICISION™ platform enables discovery of both protein degraders and protein conformation cor rectors, allowing us to match the best drug to treat each disease using patient-derived disease models to ensure successful translation into the clinic.

Origami’s lead asset is an oral pill, first-in-class protein degrader for Huntington’s disease. Multiple assets for additional indications including Frontotemporal Dementia, Alzheimer’s disease and ALS are being developed.

Origami is seeking a highly motivated individual to contribute to exciting drug discovery programs advancing therapies for neurodegenerative diseases.

The successful candidate is expected to play a key role in the Origami team, should have considerable cell culture experience, and have a strong knowledge of standard biochemical, cell and molecular biology techniques. The individual is expected to have a track record of successfully providing timely, accurate work.

• Develop, optimize and perform cell-based assays and screening strategies
• Maintain iPSC, NPC, neuronal, primary and/or other cell cultures
• Provide detailed experimental protocols and develop SOPs
• Keep accurate inventory of supplies for laboratory operations
• Keep current with scientific literature and technology developments
• Provide project leadership and supervise, mentor and train junior scientists
• Effectively communicate with team members on research progress
• Perform all other related duties as assigned; level of responsibility will depend on experience

• MS or PhD in relevant scientific field with a minimum 2-3 years of relevant experience in an industry setting
• Minimum 2 years of hands‑on mammalian cell culture experience
• Hands‑on experience developing and executing cell‑based assays, standard biochemical and/or molecular biology techniques.
• Ability to plan and execute experiments accurately, on time, and with minimal supervision
• Proficiency with standard laboratory calculations, dilutions and multi‑well plates
• Meticulous and timely record keeping
  
  Demonstrated ability to multitask and collaborate with scientists in a highly dynamic environment
• Outstanding organizational, time management, verbal and written communication skills

• Cell culture of human primary cells, neurons, stem cells or induced pluripotent stem cells (iPSCs)
• Experience using Quantitative Capillary Western, MSD and/or immunochemistry techniques
• Experience with automation / high throughput assays
• Proven track record of supervisory or mentoring skills

Origami offers a dynamic work environment and an attractive salary commensurate with experience. Additionally, Origami offers a comprehensive benefits package which includes Paid Time Off, Holidays, 401(k) plan, Company insurance coverage (Medical, Dental, Vision) and stock options. Origami is an Equal Opportunity Employer.