TEMP - Scientist, Neuroimmunology

About The Role

As part of the Neuroimmunology Research Team, the individual will contribute to the assessment of novel therapeutic approaches to target autoimmunity and inflammation in neurodegenerative and movement disorders. The candidate will support the progression of multiple drug discovery projects in the Neuroimmunology space, independently designing, performing, and validating key in‑vitro cell‑based functional assays. They will also perform experiments to understand the mechanism of action of drug candidates and present data to cross‑functional teams.

• Designing and performing experiments to support scientific activities and project goals
• Separation of human PBMC from whole blood or leukopak, and isolation of primary human leukocyte populations (T cells, CD4+ T cells, DCs) for downstream assays
• Maintain cell lines and primary cell cultures
• Perform immunological assays including lymphocyte proliferation, activation, cytokine secretion, and differentiation
• Perform basic molecular biology assays including mRNA isolation, Taq Man qPCR
• Flow cytometric analysis of immune cell subsets and analysis of data
• Perform immunoassays (MSD, ELISA, etc.) for analysis of soluble proteins in cell supernatants/murine plasma
• Maintain and update SOPs and electronic lab notebook, and write data summaries for experiments conducted
• Present data and findings to cross‑functional project teams
• Provide training and/or supervision to junior staff, as needed
• Other duties as assigned

• BS/BA degree and 4+ years of relevant lab experience, or
• MS/MA degree and 2+ years of relevant experience, immunology background preferred
• Robust experience with whole blood, PBMC, and immune cell‑based in‑vitro assays
• Expertise in cell culture and aseptic technique, involving both immortalized cell lines and primary human/murine cells
• Experience in immunoassays (ELISA, MSD, Western blot, etc.) and molecular biology techniques (mRNA isolation, qPCR)
• Experience with multicolor flow cytometric analysis is a must
• Able to explain the process behind data generated and the implications of the results
• Strong knowledge of one or more scientific disciplines, especially immunology
• Strong knowledge of scientific principles, methods, and techniques, and demonstrated ability to work with a variety of laboratory equipment/tools
• Excellent communication, problem‑solving, and analytical thinking skills
• Ability to work as part of a cross‑functional team, and present data and concepts clearly and concisely
• Demonstrated ability to meet multiple deadlines with a high degree of accuracy and efficiency, and experience prioritizing multiple projects is a plus

The pay you should reasonably expect to receive is $90,000 – $121,000 (paid hourly). Decisions depend on various factors, such as primary work location, complexity and responsibility of the role, job duties/requirements, and relevant experience and skills.

Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements.