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Post-doc in Membrane Protein Design, Molecular Biophysics, and Chemical Biology

Job in San Diego, San Diego County, California, 92189, USA
Listing for: CHARMM-GUI
Full Time position
Listed on 2025-12-02
Job specializations:
  • Research/Development
    Research Scientist
  • Healthcare
Job Description & How to Apply Below

CHARMM is a versatile program for atomic-level simulation of many-particle systems, particularly macromolecules of biological interest.

- M. Karplus

Post-doc in Membrane Protein Design, Molecular Biophysics, and Chemical Biology Date

Location

San Diego, CA;
Scripps Research

Description

Mravic Lab @ The Scripps Research Institute, La Jolla, CA campus

Title

Post-doc in Membrane Protein Design, Molecular Biophysics, and Chemical Biology

Contact

Apply to Dr. Mravic at mmravic with a cover letter, CV with publication list, and contact information for 3 references. Unpublished first-author manuscripts can be included for review. More info on lab website: https://(Use the "Apply for this Job" box below)./

Research Areas
  • Design and characterization of synthetic membrane proteins: Using protein design to hypothesize and test chemical rules and features for protein structure or function in lipid. Focuses on creating simplified membrane protein models to understand disease mechanisms, improve in silico prediction, and enable bioengineering applications.
  • Design of chemical biology tools: Developing computational algorithms to design hydrophobic mini-proteins and peptides that insert into lipid bilayers and target membrane proteins at their transmembrane regions. These tools help manipulate protein states and study disease mechanisms for therapeutic insights.
  • The lab employs computational methods like bioinformatics, modeling, and molecular dynamics, alongside experimental techniques such as NMR, X-ray crystallography, lipid cubic phase crystallography, chemical synthesis, bioconjugation, and cellular assays. Candidates with additional skills like cryo-EM are encouraged to apply.

    Basic Qualifications
    • Molecular cloning, mammalian cell culture, protein expression & purification
    • Biophysical and structural characterization of proteins (FRET, NMR, Cryo-EM, X-ray)
    • Computational biology and programming (Python, Perl, Bash, C++)
    • Proven research productivity with peer-reviewed publications
    Preferred Qualifications
    • Experience with membrane protein expression, purification, and structural biology
    • Computational biophysics, high-performance computing, GPU acceleration
    • Proficiency with molecular modeling and simulation software
    • Skills in bioinformatics, statistics, clustering, machine learning
    How to Apply

    Send your application to Dr. Mravic at mmravic with a cover letter, CV, publication list, and contact info for 3 references. Unpublished manuscripts are welcome. More info available on the lab website.

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