Computational Chemistry Senior Research Scientist
Listed on 2025-12-02
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Research/Development
Research Scientist, Drug Discovery, Biotechnology, Biomedical Science
Join to apply for the Computational Chemistry Senior Research Scientist role at Vertex Pharmaceuticals
Computational Chemistry Senior Research ScientistJoin to apply for the Computational Chemistry Senior Research Scientist role at Vertex Pharmaceuticals
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Job Description
We are seeking a highly motivated Computational Chemistry Senior Research Scientist to join Vertex’s research site in San Diego, California. This individual will be responsible for contributing to both lead identification and optimization programs using methods encompassing all computational aspects of drug discovery. This individual will work collaboratively with interdisciplinary project teams to provide expertise in cheminformatics, physics-based methods, and molecular design to deliver drug candidates.
Contributing to improving foundational computational capabilities across the department is preferred and achieved through collaboration with the global DCS group.
Job Description
We are seeking a highly motivated Computational Chemistry Senior Research Scientist to join Vertex’s research site in San Diego, California. This individual will be responsible for contributing to both lead identification and optimization programs using methods encompassing all computational aspects of drug discovery. This individual will work collaboratively with interdisciplinary project teams to provide expertise in cheminformatics, physics-based methods, and molecular design to deliver drug candidates.
Contributing to improving foundational computational capabilities across the department is preferred and achieved through collaboration with the global DCS group.
Responsibilities
- Collaborate with scientists at our San Diego drug discovery site and across our network to maximize the impact of computational efforts on drug discovery projects
- Ensure effective interdepartmental communication and implementation of in-silico work streams related to drug discovery
- Work with others in Computational Drug Design and the Chemical Data Science group to identify and apply new methodologies to increase impact of computation on drug discovery teams
- Incorporate innovative strategies and methodologies to address critical project issues
- Ph.D. (or equivalent degree) in engineering, science or math and 2-5 years of productive, relevant post-doctoral employment experience, or
- Master's Degree (or equivalent degree) in similar fields and 5+ years of productive, relevant employment experience, or
- Bachelor's Degree (or equivalent degree) in similar fields and 8+ years of productive, relevant employment experience
- Strong experience in applying molecular modeling methods to structure, ligand and fragment-based drug discovery
- Expert knowledge of the state-of-the-art for computational chemistry and its application in drug discovery, such as FEP and ML techniques
- Experience with commercial molecular modeling and data mining software
- Excellent oral and written communication skills
- Ability to multi-task and set priorities on multiple projects
- Preferred Requirements
- Expertise with a wide array of computational methods preferably including structure and ligand-based virtual screening, programming, statistics, data analysis, QSAR derivation and application, and ADME modeling
$123,400 - $185,100
Disclosure Statement
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision…
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