Synthesis Scientist

Job Title:

Scientist / Senior Scientist – Oligonucleotide Chemistry

Location:

[San Diego,CA]

Type:
Full-time

Next Gen Tides is a fast-growing biotech startup focused on oligonucleotide and conjugation technologies. We are building next-generation capabilities in ASO, siRNA, PMO, peptide conjugation, and AOC technologies to drive the future of therapeutics.

We are looking for a Scientist or Senior Scientist to join our core chemistry team. This is a rare opportunity to join early, help build the foundation of our platform, and make a tangible impact on our scientific direction.

If you are passionate about oligonucleotide synthesis, modified chemistries, and advanced analytical workflows, we want to hear from you. You will be hands‑on in the lab, executing high‑quality synthesis and purification while optimizing methods for both client projects and internal R&D.

• Oligo Synthesis: Write protocols and perform solid‑phase synthesis of DNA, RNA, ASO, siRNA, PMO, and modified oligos.
• Analysis & QC: Operate and interpret data using LC–MS (Waters) and HPLC (Agilent) to ensure purity and identity.
• Instrument Management: Maintain and troubleshoot automated oligo synthesizers (
  Mermade / Dr. Oligo ).
• Purification: Execute purification and deprotection workflows with a focus on high quality and yield.
• Innovation: Support peptide–oligo conjugates and AOC‑related chemistries, contributing to overall platform development.
• Optimization: Develop and refine synthesis and purification methods to improve efficiency for internal programs.
• Lab Operations: Maintain lab excellence, including instrument upkeep, documentation, and QC standards.

• Education: PhD in Chemistry, Chemical Biology, or a related field (0–5+ years experience) OR MS/BS with strong, hands‑on industry experience.
• Technical Expertise: Deep experience with oligonucleotide solid‑phase synthesis and automated synthesizers.
• Analytical
  
  Skills:
  
  Strong proficiency in LC–MS, HPLC, and oligo purification workflows.
• Chemistry Knowledge: Familiarity with modified backbones (PS, PO) and nucleoside chemistry.
• Soft Skills: A "startup mindset"—you are independent, organized, a clear communicator, and a proactive problem solver.

• Experience with conjugation chemistries (peptides, lipids, ligands).
• Experience building protocols from scratch in a startup environment.

• Impact: Build the foundation of a new biotech platform and see the direct result of your work.
• Equity: Ownership in the company you are helping to build.
• Compensation: Competitive base salary + potential year‑end bonus.
• Benefits: Healthcare insurance and Paid Time Off (PTO).
• Culture: A collaborative, fast‑paced environment where technical innovation is rewarded.

Ready to build the next generation of oligonucleotide therapeutics? Click Apply Now or send your resume to