Sr. Scientist, Radiopharmaceutical Development

Overview

Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.

You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.

You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

Rayze Bio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. Rayze Bio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, Rayze Bio aims to be the global leader in radiopharmaceuticals.

The Sr. Scientist, Radiopharmaceutical Development is a leading contributor in the design, development, and advancement of Rayze Bio's radiopharmaceutical programs. This senior role is responsible for translating cutting-edge scientific discoveries into robust clinical drug products and driving technology transfers. The Sr. Scientist will lead CMC radiopharmaceutical process development, oversee IND-enabling activities, and play a pivotal role in clinical manufacturing. This position demands expertise in radio chemical synthesis, analytical techniques, and radiopharmaceutical formulation, as well as a proven ability to manage complex projects and mentor junior staff.

• Process Development & Scale-Up:
  Drive CMC process development and optimization for clinical drug products, including formulation lock and robust process definition, ensuring scalability and compliance with regulatory standards.
• Technology Transfer:
  Lead the transfer of advanced radiopharmaceutical processes and technologies to internal and external manufacturing sites, including the Indianapolis facility and CDMO partners.
• Laboratory Oversight:
  Oversee the development, operation, and maintenance of radiochemistry laboratory infrastructure, ensuring readiness for translational activities from preclinical through clinical phases.
• Collaboration:
  
  Foster collaborative relationships with discovery scientists, external academic partners, and CDMOs to address complex scientific questions and pursue joint research efforts.
• Lead Research Initiatives:
  Independently design and execute advanced radiochemistry and radiolabeling experiments, with a special focus on novel radioisotope and chelator development to enable new classes of radiopharmaceuticals.
• Technical Leadership:
  Serve as a subject matter expert in radiopharmaceutical production processes, quality control, and advanced analytical methodologies. Provide scientific leadership across multidisciplinary teams.
• Safety & Compliance:
  Ensure strict adherence to radiation safety protocols, federal and state regulations, and internal guidelines for handling radioactive materials; promote a culture of safety-first and regulatory compliance.
• Data Analysis & Reporting:
  Interpret complex experimental data, draw scientifically rigorous conclusions, and communicate findings in technical reports, regulatory documentation, and presentations for internal and external stakeholders.
• Project Management & Mentorship:
  Manage and prioritize research projects, oversee third-party vendors, and mentor junior scientists and associates.
• Documentation:
  Draft and review CMC sections for regulatory submissions, SOPs, and comprehensive development reports.
• Travel:
  Less than 10% travel required, including external research sites and manufacturing facilities.

• BSc +8, MSc + 6 years or PhD +3 years in Chemistry, Radiochemistry, Pharmaceutical Sciences, or related field with relevant industry experience, including significant CMC work with radiopharmaceutical products.
• Experience in radiopharmaceutical companies leading technology…