Senior Scientist R&D

Natera is seeking a skilled Senior Scientist to join our Molecular Biology Research Team. As a Senior Scientist, you will design and execute epigenomics-based research to develop new methods that expand Natera’s oncology product portfolio. Successful candidates must have NGS experience with a strong background in molecular biology and methylation detection techniques.

• Contribute substantially and intellectually to research and development.
• Lead projects to create novel methylation-based diagnostic tests; including planning, testing, protocol development, optimization, and transfer to Development.
• Responsible for maintaining a project timeline, including deliverable planning/management and communication of progress directly with manager and colleagues.
• Independently develop plans, generate and advance new ideas.
• Design and execute high complexity experiments and perform basic data analysis as needed (e.g. R, JMP, Excel).
• Coordinate complex analyses with statistics and bioinformatics teams.
• Actively interact and communicate with interdepartmental teams such as Program Management, Bioinformatics, Data Science, Engineering, Translational Science, and Product.
• May manage junior scientists and research associates.
• Document research progress under a Quality Management System.

• Ph.D. in molecular biology, genomics, or a closely related field.
• Minimum 5 years of relevant industry experience, or successful postdoctoral research with 3+ years in industry.

• Extensive hands‑on experience with NGS methods, including sample prep, library prep, target enrichment (e.g., multiplex PCR, hybrid capture), and sequencing.
• Experience with epigenomic/methylation techniques and cfDNA is a plus.
• A background in oncology is strongly preferred.
• Must have strong research skills and sound scientific judgement with a proven track record of conceptualizing, prototyping, and advancing NGS technologies from initial concept to product development.
• Significant experience in developing and executing automated assays on liquid handlers (e.g. Hamilton, Tecan).
• Demonstrated ability to lead projects and contribute strategically to a team‑driven research environment.
• Excellent communication, organizational, record‑keeping, planning, time management, analytical and problem‑solving skills.
• Proficient with analysis tools such as Excel, JMP, R, or Python; familiarity with bioinformatics workflows is a plus.
• Skilled at writing clear plans, reports and SOPs.

This range reflects a good‑faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.

• Annual performance incentive bonus
• Long‑term equity awards
• Comprehensive health benefits (medical, dental, vision)
• 401(k) with company match
• Generous paid time off and company holidays
• Additional wellness and work‑life benefits

Compensation Range

$138,100—$172,600 USD

Natera™ is a global leader in cell‑free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world‑class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

Competitive Benefits – Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby…