Associate Scientist II; TFF​/HPLC

We are hiring an Associate Scientist II to support our biotechnology client's R&D project. You will contribute to the setup, synthesis, purification, and analytical characterization. The ideal candidate will have an excellent understanding of conjugation process development, analytical chemistry principles, and substantial hands-on laboratory experience. The successful candidate will be expected to independently optimize and troubleshoot upstream and downstream conjugation processing procedures with minimal guidance.

The candidate will also contribute across a range of related areas, including analytical development, stability studies, and process optimization initiatives. Responsibilities will also include record management, presenting data at group meetings, and contributing to the authorship of laboratory protocols and development reports.

This is a 12-month contract in San Carlos, California.

• Set up, optimize, and troubleshoot multi-step syntheses of protein-polysaccharide conjugates using click-chemistry and other related chemistries.
• Purify polysaccharides and conjugates using a variety of methods, including dialysis, FPLC chromatography, and tangential flow filtration (TFF).
• Characterize protein/polysaccharide/conjugates using different analytical methods, including SDS-PAGE gel, Western blotting, ELISA, HPLC, SEC-MALS, colorimetric and dynamic binding assays, et al.
• Apply Design of Experiments (DoE) principles; design, execute, and interpret statistically modeled experiments using DoE software.
• Proactively contribute scientific ideas, experimental strategies, and process improvements.
• Independently review and summarize relevant scientific literature to inform experimental design.
• Maintain highly organized records and Benchling entries to enable optimization and assessment of reproducibility.
• Analyze, interpret, and clearly communicate experimental data, including identifying trends, anomalies, and recommending next steps.
• Execute established protocols with limited oversight, demonstrating strong technical proficiency.
• Support team in routine laboratory activities and instrument maintenance.

• BS. in Chemistry, Biochemistry, or related field or a related discipline, with minimum 2 years of relevant industry experience. MS without experience; or equivalent work experience.
• Strong understanding of underlying scientific concepts, process development, and analytical assay principles.
• Extensive hands-on experience in purification methods such as diafiltration, depth filters, and TFF required.
• Prior hands-on experience in the conjugation process development is highly desirable.
• Proficiency with common protein/polysaccharide/conjugates analytical techniques, including SDS-PAGE, Western blotting, ELISA, HPLC, and SEC-MALS, is required.
• $106,080-$116,480

As an employee, you have access to a comprehensive benefits package including:

• Medical insurance – PPO, HMO & HSA
• 401k plan
• Employee Assistance Program
• Long-term disability
• Weekly payroll
• Online timecard approval

R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering. We provide job opportunities within major pharmaceutical, biopharmaceutical, biotechnology, and medical device companies.

R&D Partners is an equal-opportunity employer.