Manager, NGS Operations

Overview

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The Manager, NGS Operations oversees lab personnel and daily operations of sequencing instruments in support of research and development projects. The ideal candidate is technically proficient and people-focused, able to balance hands-on problem solving with mentoring and developing a high-performing team.

• Manage daily scheduling and oversight of employees performing next generation sequencing (NGS) while fostering a collaborative, accountable, and growth-oriented team culture
• Manage Illumina sequencing workflows (Nova Seq X, Nova Seq 6000, MiSeq i100, etc.)
• Monitor run level performance metrics (error rate, %
  Q30, cluster pass filter, % occupancy, etc) and troubleshoot instrument or library issues as needed
• Oversee Pac Bio Sequel and Revio operations, including instrument loading, run setup, and monitoring of key performance metrics (e.g., read length distribution, yield, accuracy/Q-scores), and troubleshoot instrument or library-related issues as needed
• Lead continuous improvement initiatives to optimize throughput, reduce turnaround times, and minimize errors, balancing speed with quality
• Serve as the primary point of contact for sequencing-related questions and workflow decisions, communicating clearly and proactively with stakeholders
• Maintain accurate records of lab work, ensure compliance with SOPs, and champion best practices in documentation and process adherence
• Collaborate closely with peer groups in Scientific Operations to align sample processing and sequencing workflows with project goals
• Provide hands-on support for troubleshooting and workflow optimization, while coaching team members to develop independence and confidence in their technical problem-solving
• Present team activity summaries, project updates, and performance metrics to management, highlighting successes, challenges, and opportunities for innovation
• Contribute to budget planning, capital equipment purchases, and vendor management for sequencing platforms and consumables, ensuring resources meet both current and future needs

• BS/BA in a biological science or equivalent required; advanced degree preferred
• 5 years of related experience, 2+ years in a supervisory or leadership role

• Hands-on experience with library preparation and next generation sequencing platforms, including Illumina (Nova Seq 6000, Nova Seq X, MiSeq i100) and Pac Bio (Sequel, Revio)
• Hands-on experience with nucleic acid techniques (isolation, purification, sonication, quantification, ampification, hybridization capture, etc.)
• Familiarity with laboratory automation a plus (Hamilton, Tecan, Biomek, Qiasymphony)
• Able to recognize lab issues and team concerns, communicate to management, and suggest improvements
• Knowledge of LIMS/database software
• Proficiency with Microsoft Office and Google Drive programs
• Excellent oral and written communication skills
• Ability to think creatively and analytically with strong troubleshooting and problem-solving skills
• Strong leadership and mentoring skills with a proven ability to motivate and develop technical staff
• Experience managing vendor contracts and evaluating technology platforms for lab implementation
• Ability to thrive in a fast-paced, evolving environment, and manage competing priorities efficiently

Pay range: $109,700—$137,200 USD.

Location:

San Carlos, CA.

Natera is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also…