Synthetic​/Organic Chemist

Overview

Medi Beacon Inc. Overview

Medi Beacon is a medical technology company focused on advancing fluorescent tracer agents and transdermal detection technology to provide vital and actionable measurement of organ function. The company is focused on bringing to market innovative products to meet large unmet medical needs while helping reduce overall health care costs.

The Synthetic Organic Chemist will contribute to our R&D efforts by working with a multidisciplinary team responsible for the technical development of the Medi Beacon fluorophore platform. The role provides high-level organic synthesis support to current research activities, product development scientists, manufacturing groups, and special project teams. The candidate will collaborate with senior management on new project proposals to discover new clinical applications of our fluorophore platform and to develop new fluorophores with unique fluorescent and biological properties.

Collaboration with process development partners will help identify significant fluorophore process improvements, and with patent counsel to protect Medi Beacon inventions.

Description Summary

The Synthetic Organic Chemist will be part of a rapidly growing technical team focused on bringing innovative products to market to meet medical needs and reduce health care costs.

• The primary responsibility will be the synthetic effort to further develop existing fluorophores and to identify, synthesize, purify and obtain molecular characterization for new patentable fluorophores with potential to become the next generation of diagnostic agents.
• Collaborate with the process group to develop and implement commercially viable process improvements in a timely manner.
• Assist with patent preparation and prosecution.
• Work with analytical chemistry colleagues to maintain instrumentation and troubleshoot hardware and software issues.
• Interpret analytical data from LCMS and apply scientific expertise to solve problems.
• Direct and interpret NMR studies (1D and 2D), assist with mass spec data interpretation, and identify outside collaborators for additional analysis (e.g., elemental analysis, FTIR, X-ray structure determination) as needed.
• Manage deliverables against timelines.
• Draft, review, and/or approve batch records, process validation protocols, design verification protocols, and CMC regulatory filings as appropriate.
• Apply scientific fundamentals to troubleshoot formulation, stability, and manufacturing issues.
• Record observations and correlate data; prepare detailed research reports for internal and external needs, including publications.
• Manage relationships with collaborators and vendors; communicate constructively with other scientists and managers.
• Serve as the technical lead in cross-functional project teams.
• Assist in drafting, reviewing, and revising department SOPs and other technical documents.
• Mentor junior colleagues and ensure laboratory safety.

Base salary compensation will be commensurate with the experience of the individual who is hired.

Company Benefits Include Access To The Following

• Healthcare – Medical, Dental and Vision
• HSA
• 401(k) Plan
• PTO Policy
• Educational Assistance Program
• Medi Beacon Inc. Equity Incentive Program
• Life Insurance and AD&D and Accident Coverage
• Disability Insurance – Short-term and Long-term

PhD in Synthetic or Physical Organic Chemistry or related fields with 5+ years of relevant academic or industrial experience; or a Master of Science in Organic Chemistry or related fields with 5+ years; or a Bachelor’s degree in Chemistry or related fields with 10+ years of academic or industrial experience.

Extensive hands-on experience and in-depth knowledge of NMR (proton and carbon 1D and 2D techniques), analytical chromatography methodologies (HPLC/UPLC), preparative chromatography methodologies (reverse phase and normal phase), and other molecular characterization techniques (mass spec, high resolution MS, MS/MS, elemental analysis, FTIR, etc.).

• Well-versed in regulatory requirements to assure appropriate design and execution of drug development and manufacturing activities.
• In-depth knowledge in manufacturing processes, quality, and regulatory requirements.
• Excellent technical writing skills and attention to detail in authoring methods, specifications, and technical reports; assistance with regulatory filing documents where appropriate.
• Demonstrated experience working collaboratively in cross-functional and cross-cultural teams.
• Familiarity with process improvement strategies and method transfer to production units, validation, impurity identification and minimization/elimination.
• Familiarity with a range of analytical techniques to analyze and quantify small molecules.
• Experience with small molecule mass spectrometry is a plus, including impurity identification and structure elucidation skills.
• Ability to manage multiple projects/priorities simultaneously.