Postdoc - Therapeutic Epigenetic Editing in vivo

Organisation/Company European Molecular Biology Laboratory Research Field Biological sciences Researcher Profile Recognised Researcher (R2) Final date to receive applications 11 Mar 2026 - 23:00 (UTC) Country Italy Type of Contract To be defined Job Status Full-time Hours Per Week To be defined Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure?

No
Offer Description
Your group
Hackett

Your role
You will lead an in vivo epigenome editing programme focused on the delivery of epigenetic editors in mouse liver to modulate target gene expression. Based at EMBL, and working jointly with biotech partners, you will be responsible for the implementation of in vivo workflows, including mouse dosing with AAV and/or LNP, coordinated tissue collection, and downstream molecular and genomics analyses. The goal is to engineer therapeutic changes in target gene expression.
The role offers a unique opportunity to work at the academic–industry interface, providing exposure to translational research, biotech operating models, and clinically oriented decision-making. The position operates to experimental plans and milestones and is thus well suited to candidates who value structured, high-quality experimental execution. There is access to state-of-the-art technologies and full mouse husbandry support, as well as training in mouse biology.

There is also the oppurtunity to lead and supervise a small team of researchers to achieve the experimental goals. This position is thus an excellent bridge for highly motivated scientists seeking to build future leadership careers in translational biology or biotechnology.
You have
PhD in Gene Therapy, Epi(genomics) or a related field, and proven research experience in a relevant field.

Experience with mouse biology, including working with AAV and/or LNP delivery
Strong experience of core molecular biology techniques (qRT-PCR, ChIP, cloning etc) and analysis.
Motivation to work in an international team bridging academia and biotech, to develop technologies towards clinical translation.
Good communication and interpersonal skills
Fluency in English is essential
You may also have

Experience with liver biology and diseases.
A working understanding or experience with CRISPR design and implementation
Ability to analyse genomics data, including RNA‑seq or ChIP‑seq
2 years, with potential to be extendable upto 5 years.
At least 3.228 EURO/month after tax
The EMBL Fellows’ Career Service provides support and guidance to predoctoral and postdoctoral fellows across all six EMBL’s sites.
Working with a dedicated Careers Advisor, this invaluable service will help you to take informed decisions about your career planning both in the short and longer term. Whether your main interest is pursuing a career path in academia, exploring opportunities in industry or exploring an independent venture, the EMBL Fellows’ Career Service with provide you with a portfolio of activities and resources to help you.
Financial incentives:

Monthly family and child allowances, generous stipend reviewed yearly, pension scheme, death benefit and unemployment insurances
Flexible working arrangements including hybrid working patterns
Private medical insurance for you and your immediate family
Generous time off:30 days annual leave per year in addition to public holidays
Campus life:

Free shuttle bus (Heidelberg), on‑site library, subsidised on‑site cafeteria, casual dress code, extensive sports and social club activities (on campus and remotely)
Family benefits:
Kindergarten (Heidelberg), 10 days of child sick leave, paid maternity & parental leave, holiday clubs on campus and monthly family and child allowances
What else you need to know
International applicants:
We recruit internationally and successful candidates are offered visa exemptions. Read more on our page for international applicants.
Diversity and inclusion:
At EMBL, we believe that diverse teams drive innovation and scientific excellence. We encourage applications from candidates of all genders, identities, nationalities and/or any other diverse backgrounds.

Job location:

All our fellowships are based on‑site (for at least part of each week). If you are living overseas, you will receive a generous relocation package to support you.
EMBL is a signatory of DORA. Find out how we apply DORA principles to our recruitment and performance assessment processes here

How to apply:

To apply please submit a cover letter and a CV through our online system. Applications will close at 23:59 CET on the date shown below. We aim to provide a response within two weeks after the closing date.
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