Scientist, Research Scientist

Arcellx is a public, clinical‑stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible.

Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California. At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work.

Living our core values is essential to maintaining a work environment that is high‑performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team.

• Start with authenticity:
  We foster an inclusive environment where each person can bring their authentic self to work.
• Think “we” before “me”:
  We prioritize collective success, collaborating and supporting one another to achieve our shared goals.
• Embrace the challenge:
  We deliver exceptional results by working with shared determination and a commitment to doing what’s right.

As a scientist within our Cell Biology group, you will have a direct impact on our drug pipeline as a lab‑based contributor and functional area lead within the project setting. Our potentially life‑saving treatments would not exist without the work of our talented scientists. Your work as a member of our experienced cross‑functional team will drive discovery, characterization, and optimization of novel cell‑based therapies.

• Contribute to one or more pipeline programs, working collaboratively with cross‑functional teams to ensure the timely generation and dissemination of critical program data to enable data‑driven decisions.
• Design and execute experiments independently with minimal supervision, as well as effectively plan and organize work activities and prioritize task completion.
• Serve as a functional area lead within a project setting, helping to derive timelines, plans, and execution to help achieve project goals.
• Stay up to date with relevant technical and intellectual scientific expertise in tumor biology and cancer modelling, particularly as it relates to CAR‑T cell biology or other cell‑based therapies.

• Candidates with a master’s degree and 4‑6+ years research experience within the pharmaceutical industry or a PhD‑level scientist from a relevant field and 0‑2 years industry experience.
• Specific backgrounds of interest are:
• Chimeric Antigen Receptor (CAR) T‑cells or alternative cell‑based cancer therapeutics
• Other Immunomodulatory drug modalities (T‑cell engagers or multi‑specific proteins)
• Autoimmune diseases research (E merging therap ies , p athogenic mechanisms, immune tolerance & reset, signaling pathway s )
• Expertise in manipulating immune cells, particularly T cells, including purification, transfection/transduction, activation and expansion, and cryopreservation.
• Familiarity with markers of memory, exhaustion, and activation for phenotyping of CAR‑T cells by flow cytometry.
• Expertise in immune cell assays including multiparameter flow cytometry, in vitro cell‑based assays (e.g., cytotoxicity, proliferation, degranulation), live cell analysis (Incu Cyte), cytokine measurement (ELISA or Lumit), and multiplex assays. Preferably experience on BD instruments or Cytek Aurora for flow cytometry.
• Expertise in basic cell line manipulation, including transient transfection, CRISPR knockout, antigen over-expression, and single‑cell cloning.
• Expertise in basic molecular biology techniques, including genomic DNA extraction and qPCR for vector copy number measurement.
• Familiarity with methods to pre‑clinically assess efficacy, specificity, and safety of CAR‑T cells or other novel immuno‑oncology agents.
• Familiarity with in vivo models of human cancer, including cell line…